Role of Helper T cells on Helicobacter pylori-induced gastritis.

• Project/Area Number: 21790476
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: NAGAI Shigenori Keio University, 医学部, 助教 (50348801)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: Helicobacter pylori / Th17 / ヘルパーT細胞 / ケモカイン

Research Abstract

I demonstrated that although IL-17A was not required for neutrophil infiltration into the gastric lamina propria (gLP) in Helicobacter pylori-induced gastritis, infiltrating Th1 cells caused more severe gastritis with massive neutrophil infiltration into gLP.

Research Products

• [Journal Article] Listerial invasion protein internalin B promotes the entry into ileal Peyer's patches in vivo. (2011)
  • Author(s): Chiba S, Nagai T, Hayashi T, Baba Y, Nagai S, Koyasu S.
  • Journal Title: Microbiol Immunol vol.55(2) Pages: 123-9
  • NAID: 10031121450
  • Peer Reviewed
• [Journal Article] Listerial invasion protein internalin B promotes the entry into ileal Peyer's patches in vivo. (2011)
  • Author(s): Chiba S, Nagai T, Hayashi T, Baba Y, Nagi S, Koyasu S.
  • Journal Title: Microbioiogy and Immunology Volume: 55(2) Pages: 123-129
  • NAID: 10031121450
  • Peer Reviewed
• [Journal Article] Bordetella Evades the Host Immune System by Inducing Il-10 through a Type III Effector,BopN. (2009)
  • Author(s): Nagamatsu K, Kuwae A, Konaka T, Nagai S, Watanabe M, Yoshida S, Mimuro H, Koyasu S, Abe A.
  • Journal Title: J Exp Med vol.206(13) Pages: 3073-3088
  • Peer Reviewed
• [Journal Article] Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. (2009)
  • Author(s): Jinushi M, Sato M, Kanamoto A, Itoh A, Nagai S, Koyasu S, Dranoff G, Tahara H.
  • Journal Title: J Exp Med vol.206(6) Pages: 1317-1326
  • Peer Reviewed
• [Journal Article] Inflammatory cytokines and hypoxia contribute to ^<18>F-FDG uptake by cells involved in pannus formation in rheumatoid arthritis. (2009)
  • Author(s): Matsui T, Nakata N, Nagai S, Nakatani A, Takahashi M, Momose T, Ohtomo K, Koyasu S.
  • Journal Title: J Nucl Med vol.50(6) Pages: 920-926
  • Peer Reviewed
• [Journal Article] Critical Roles of NK and CD8^+ T Cells in Central Nervous System Listeriosis. (2009)
  • Author(s): Hayashi T, Nagai S, Fujii H, Baba Y, Ikeda E, Kawase T, Koyasu S.
  • Journal Title: J Immunol vol.182(10) Pages: 6360-6368
  • Peer Reviewed
• [Journal Article] Bordetella Evades the Host Immune System by Inducing II-10 through a Type III Effector, BopN. (2009)
  • Author(s): Nagamatsu K, Kuwae A, Konaka T, Nagai S, Watanabe M, Yoshida S, Mimuro H, Koyasu S, *^Abe A.
  • Journal Title: The Journal of Experimental Medicine 206 Pages: 3073-3088
  • Peer Reviewed
• [Journal Article] Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. (2009)
  • Author(s): Jinushi M, Sato M, Kanamoto A, Itoh A, Nagai S, Koyasu S, Dranoff G, *^Tahara H.
  • Journal Title: The Journal of Experimental Medicine 206 Pages: 1317-1326
  • Peer Reviewed
• [Journal Article] Inflammatory cytokines and hypoxia contribute to <18>^F-FDG uptake by cells involved in pannus formation in rheumatoid arthritis. (2009)
  • Author(s): Matsui T, Nakata N, Nagai S, *^Nakatani A, Takahashi M, Momose T, Ohtomo K, *^Koyasu S.
  • Journal Title: The Journal of Nuclear Medicine 50 Pages: 920-926
  • Peer Reviewed
• [Journal Article] Critical Roles of NK and CD8^+ T Cells in Central Nervous System Listeriosis. (2009)
  • Author(s): Hayashi T, Nagai S, Fujii H, Baba Y, Ikeda E, Kawase T, *^Koyasu S.
  • Journal Title: The Journal of Immunology 182 Pages: 6360-6368
  • Peer Reviewed
• [Presentation] 生体内で優れた抗菌活性を有するインプラントの開発 (2010)
  • Author(s): 船尾陽生, 石井賢, 永井重徳, 佐々木あや, 干川智之, 相澤守, 岡田保典, 千葉一裕, 小安重夫, 戸山芳昭, 松本守雄
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都国際会館.京都
  • Year and Date: 2010-10-14
• [Presentation] In vivo imagingを用いた定量的マウス慢性骨髄炎モデルの確立 (2010)
  • Author(s): 船尾陽生, 石井賢, 永井重徳, 佐々木あや, 干川智之, 相澤守, 岡田保典, 千葉一裕, 小安重夫, 戸山芳昭, 松本守雄
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都国際会館.京都
  • Year and Date: 2010-10-14
• [Presentation] Establishment of a novel collagen-induced arthritis model by manipulating dendritic cells. (2010)
  • Author(s): Shigenori Nagai
  • Organizer: The 11^<th> International Symposium on Dendritic Cells
  • Place of Presentation: ルガーノ(スイス)
  • Year and Date: 2010-09-29
• [Presentation] Establishment of a novel collagen-induced arthritis model by manipulating dendritic cells. (2010)
  • Author(s): Nagai S, Katori R, Oyama M, Koyasu S.
  • Organizer: The 11^<th> International Symposium on Dendritic Cells.
  • Place of Presentation: Lugano, Switzerland.
  • Year and Date: 2010-09-28
• [Presentation] Role of phosphoinositide 3-kinase on helper T cell differentiation in Helicobacter pylori-induced gastritis. (2010)
  • Author(s): Nagai S, Kurebayashi Y, Baba Y, Koyasu S.
  • Organizer: 14^<th> International Congress of Immunology.
  • Place of Presentation: 神戸国際会議場.兵庫
  • Year and Date: 2010-08-25
• [Presentation] Role of phosphoinositide 3-kinase on helper T cell differentiation in Helicobacter pylori-induced gastritis. (2010)
  • Author(s): Shigenori Nagai
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2010-08-25
• [Presentation] Establishment of a novel collagen-induced arthritis model by manipulating dendritic cells. (2010)
  • Author(s): Katori R, Oyama M, Nagai S, Koyasu S.
  • Place of Presentation: 神戸国際会議場.兵庫
  • Year and Date: 2010-08-24
• [Presentation] Regulation of Th17 cell differentiation by PI3K-Akt-mTORC1 axis. (2010)
  • Author(s): Kurebayashi Y, Nagai S, Baba Y, Koyasu S.
  • Organizer: 14^<th> International Congress of Immunology.
  • Place of Presentation: 神戸国際会議場.兵庫
  • Year and Date: 2010-08-23
• [Presentation] Reoxygenation accelerates the differentiation of Th17 cells primed under hypoxia. (2010)
  • Author(s): Ikejiri A, Nagai S, Koyasu S.
  • Place of Presentation: 神戸国際会議場.兵庫
  • Year and Date: 2010-08-23
• [Presentation] 細菌感染における宿主免疫応答 (2010)
  • Author(s): 永井重徳、小安重夫
  • Organizer: 第11回Pharmaco-Hematologyシンポジウム
  • Place of Presentation: 日本薬学会館(東京).東京
  • Year and Date: 2010-06-18
• [Presentation] 細菌感染における宿主免疫応答 (2010)
  • Author(s): 永井重徳
  • Organizer: 第11回Pharmaco-Hematologyシンポジウム
  • Place of Presentation: 日本薬学会館(東京)(招待講演)
  • Year and Date: 2010-06-18
• [Presentation] Regulation of Th17 cell differentiation by PI3K-Akt-mTORC1 axis. (2009)
  • Author(s): Kurebayashi Y, Nagai S, Baba Y, Koyasu S.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場.兵庫
  • Year and Date: 2009-10-22
• [Presentation] Establishment of Quantitative Model of Staphylococcal Osteomyelitis Using Bioimaging Techniques. (2009)
  • Author(s): Funao H, Ishii K, Nagai S, Sasaki A, Hoshikawa T, Aizawa M, Okada Y, Chiba K, Koyasu S, Toyama Y, Matsumoto M.
  • Organizer: The 9^<th> World Congress on Inflammation.
  • Place of Presentation: 京王プラザホテル.東京
  • Year and Date: 2009-07-08
• [Presentation] Role of PI3K-mTOR pathway in Th17 cell differentiation. (2009)
  • Author(s): Kurebayashi Y, Nagai S, Baba Y, Koyasu S.
  • Organizer: The 9^<th> World Congress on Inflammation.
  • Place of Presentation: 京王プラザホテル.東京
  • Year and Date: 2009-07-08
• [Presentation] Role of IL-17A in Heliocbacter pylori-induced gastritis. (2009)
  • Author(s): Nagai S, Kurebayashi Y, Baba Y, Koyasu S.
  • Organizer: The 9^<th> World Congress on Inflammation.
  • Place of Presentation: 京王プラザホテル.東京
  • Year and Date: 2009-07-08
• [Presentation] Critical roles of NK and CD8^+ T cells in central nervous system listeriosis. (2009)
  • Author(s): Hayashi T, Nagai S, Fujii H, Baba Y, Ikeda E, Kawase T, Koyasu S.
  • Organizer: The 17^<th> International Symposium of Macrophage Molecular and Cell Biology 2009.
  • Place of Presentation: KKRホテル金沢.石川
  • Year and Date: 2009-07-03
• [Presentation] The role of helper T cells in Helicobacter pylori-induced gastritis. (2009)
  • Author(s): Nagai S.
  • Organizer: GI Executive Meeting 2009.
  • Place of Presentation: 京都ブライトンホテル.京都
  • Year and Date: 2009-06-19
• [Presentation] The role of helper T cells in Helicobacter pylori-induced gastritis. (2009)
  • Author(s): Shigenori Nagai
  • Organizer: GI Executive Meeting 2009
  • Place of Presentation: 京都
  • Year and Date: 2009-06-19
• [Book] 臨床粘膜免疫学 (2010)
  • Author(s): 清野宏(編集), 他
  • Total Pages: 722
  • Publisher: 株式会社シナジー
• [Remarks] ホームページ等
  • URL: http://www.koyasu.umin.ne.jp/
• [Remarks]
  • URL: http://www.koyasu.umin.ne.jp/
• [Remarks]
  • URL: http://www.umin.ne.jp/koyasu/