| Project/Area Number |
21790485
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
DASHTSOODOL Nyambayar 独立行政法人理化学研究所, 免疫制御研究グループ, 客員研究員 (50443057)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ナチュラルキラーT(NKT)細胞 / 抗原提示分子CD1d / 胸腺 / 分化 / 前駆細胞 / CD1d |
|---|
| Research Abstract |
The presently held opinion, called "mainstream model of development", proposes that the NKT cells are developed after CD4, CD8-double-positive(DP) thymocytes. However, we have reported previously about identification of NKT cell precursors in the double-negative 4(DN4) stage of development that is before reaching DP stage, indicating NKT cells arise from earlier stage. Here, we characterized NKT precursor cells in DN4 stage by single cell sorting and qRT-PCR analysis, and also role of CD1d in the development of NKT cells by using NKT-cloned mice with CD1d-deficient background. Better understanding of developmental aspects of NKT cell lineage will hopefully lead to the development of more efficient clinical intervention methods to fight various immune-compromised diseases.
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