Elucidation of mechanisms regulating impulsivity in the developmental disorders and its pharmacotherapy : From a viewpoint of brain reward system
| Project/Area Number |
21790515
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagasaki International University (2010-2011)
Hokkaido University (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 発達障害 / 注意欠如多動性障害 / 衝動性 / SHRSP/Ezo / SHR亜系 / 行動解析 / 網羅的一塩基遺伝子多型解析 / 幼若期ストレス / 薬物治療 / SHRSP / Ezo / premature response / セロトニン・ノルアドレナリン再取込阻害薬 |
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| Research Abstract |
In this study, to elucidate the mechanisms regulating impulsivity in the developmental disorders, I mainly explored the key neuronal molecules related to the expression/formation of impulsive behaviors in model rats of developmental disorder. I investigated using the juvenile stroke-prone spontaneous hypertensive rat (SHRSP/Ezo: Ezo) as an appropriate animal model of "attention deficit hyperactivity disorder (ADHD)" and we also used juvenile SHRSP/Izm (Izm) and SHRSP/Ngsk (Ngsk) which are similar to genetic background of Ezo in the SHR substrain. In comparison with juvenile WKY/Ezo which is a genetic control for Ezo, impulsive behavior in the elevated plus-maze test only observed in the Ezo, but not Izm and Ngsk, which behavioral properties were specific for Ezo. Base on the behavioral result, I explored the polymorphic regions linked Ezo-specific behavior differ from that of Izm and Ngsk using the database determined by global analysis of single nucleotide polymorphism (SNP). 137 SNPs linked Ezo-specific behavior were identified in the 21,032 candidate genes based on SNPs of Brown Norway rat. These SNPs linked Ezo-specific behavior were retained on the chromosome 7, 9 and X-chromosome. These findings suggested that genetic background associated with impulsive behavior in the Ezo as an ADHD model rat was related to the SNPs on the chromosome 7, 9 and X-chromosome and functional molecules linked to the development and formation of neuronal cells.
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Report
(3 results)
Research Products
(77 results)
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[Journal Article] Serotonin1A receptormadiated synaptic responses in the rat medial prefrontal cortex is altered by early life stress: In vivo and in vitro electrophysiological studies2011
Author(s)
Kimura S, Togashi H, Matsumoto M, Shiozawa T, Ishida J, Kano S, Ohashi A, Ishikawa S, Yamaguchi T, Yoshioka M, Shimamura K.
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Journal Title
Jpn J Neuropsychopharmacol
Volume: 31
Pages: 9-15
URL
Related Report
Peer Reviewed
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