Molecular mechanisms involved in human transplacental transport of anionic drug

Research Project

Project/Area Number	21790518
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Applied pharmacology
Research Institution	The University of Tokyo
Principal Investigator	SATOH Hiroki The University of Tokyo, 大学院・薬学系研究科, 助教 (80451855)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	薬物胎盤透過 / アニオン性薬物 / トランスポーター / 非ステロイド性消炎鎮痛薬 / トロホブラスト細胞
Research Abstract	The transport of nonsteroidal anti-inflammatory drugs (NSAIDs) in trophoblast cells isolated from human placenta was suggested to be mediated by carrier(s), and be attributed, at least in part, to monocarboxylate transporter (MCTs). The transcellular transport of NSAIDs was examined by using isolated trophoblast cells for the first time. The present experimental system is suggested to be a potential tool to easily predict the transplacental transport of drugs in vitro.

Report

(3 results)