Mechanism of cancer cell specific recognition by microbiological toxin
Project/Area Number |
21790523
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Applied pharmacology
|
Research Institution | Kyushu Institute of Technology (2010) Kyushu University (2009) |
Principal Investigator |
KUSAKA Masatomo Kyushu Institute of Technology, 情報工学部, 支援研究員 (30529102)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 微生物毒素 / 抗癌作用 / 癌 / 薬物治療 / 微生物性毒素 |
Research Abstract |
Parasporin-2 (PS2) is a Bacillus thuringiensis inclusion protein that intensively reacts in vitro with human hepatoma and colon cancer cells. Here we tried to trace for Parasporin-2 in vivo, using Alexa488 fluorescent labeled parasporin-2. Then, Alexa488-labeled parasporin-2 was intravenously injected to subcutaneously inoculated mice with KLN205 cell, derived from mouse lung cancer cell line. we could observe fluorescence from Alexa488-labeled parasporin-2 only from transplanted tumor tissue. Thus, our primal results on anti- tumor toxin in vivo may contribute to new therapeutic application by Bt toxin on medical field.
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Report
(3 results)
Research Products
(9 results)