| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
We have identified six amino acid substitutions in the Gag region in in vitro selected amprenavir (APV)-resistant viruses. An infectious recombinant HIV-1 clone carrying the Gag mutations developed APV resistance more quickly than wild-type HIV-1, however it delayed the acquisition of resistance against nelfinavir (NFV) which is another PI, suggesting that antiretroviral regimens including both APV and NFV may bring about favorable antiviral efficacy. The present data suggests that the preexistence of certain Gag mutations related to PI resistance can accelerate the emergence of resistance to the PI and delay the acquisition of HIV resistance to other PIs. These findings should have clinical relevance in the therapy of HIV-1 infection with PI-including regimens.
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