Pathological mechanism for interferon-induced depression

• Project/Area Number: 21790529
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YAMANAKA Hajime 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, リサーチアソシエイト (10415573)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: PETイメージング / 霊長類 / 活動量 / セロトニンレセプター / セロトニントランスポーター / うつ病 / インターフェロン

Research Abstract

In order to evaluate interferon-induced changes in locomotor activity and serotonergic nervous system, we established evaluating system containing both activity monitoring system using video and positron emission tomography(PET) imaging of two proteins related to serotonergic neurotransimission. We clarified temporal changes in total duration of normal activity as well as distributions of two PET tracer accumulations in monkey brain. In addition, effect of anesthetized state on the PET imaging was investigated.

Research Products

• [Journal Article] An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys : In vivo Positron Emission Tomography Imaging of Glial Activation (2012)
  • Author(s): Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids (2011)
  • Author(s): Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergstrom M, Onoe H, Langstrom B, Watanabe Y
  • Journal Title: PET study with[^<11> C] vorozole. Neuroreport Volume: 22 Pages: 326-330
  • Peer Reviewed
• [Journal Article] Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model (2011)
  • Author(s): Ito Y, Shimazawa M, Inokuchi Y, Yamanaka H, Tsuruma K, Imamura K, Onoe H, Watanabe Y, Aihara M, Araie M, Hara H
  • Journal Title: Eur J Neurosci Volume: 33 Pages: 843-855
  • Peer Reviewed
• [Journal Article] Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates : PET study with R-^<11> C-verapamil and 11C-oseltamivir (2011)
  • Author(s): Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
  • Journal Title: J Nucl Volume: 52 Pages: 950-957
  • Peer Reviewed
• [Journal Article] Mapping of serotonin transporters by positron emission tomography with[^<11> C] DASB in conscious common marmosets : comparison with rhesus monkeys (2010)
  • Author(s): Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H
  • Journal Title: Synapse Volume: 64 Pages: 594-601
  • Peer Reviewed
• [Presentation] 麻酔薬の[^<11> C] DASB結合能に対する影響:マカクザルを用いた検討 (2012)
  • Author(s): 山中創、大野正裕、森智子、武田千穂、平尾有日子、安藤亜美、横山ちひろ、土居久志、尾上浩隆
  • Organizer: 日本分子イメージング学会
  • Place of Presentation: 浜松
  • Year and Date: 2012-05-25
• [Presentation] 無麻酔下アカゲザルのセロトニン1Bレセプターイメージング-[^<11> C] AZ10419369を用いたPET研究- (2011)
  • Author(s): 山中創、横山ちひろ、大野正裕、武田千穂、平尾有日子、倉井佐知、土居久志、尾上浩隆
  • Organizer: 日本分子イメージング学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-26
• [Presentation] 無麻酔下アカゲザルのセロトニン1Bレセプターイメージング-[^<11>C]AZ10419369を用いたPET研究- (2011)
  • Author(s): 山中創、横山ちひろ、大野正裕、武田千穂、平尾有日子、倉井佐知、土居久志、尾上浩隆
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸(神戸国際会議場)
  • Year and Date: 2011-05-26
• [Presentation] Influence of propofol anesthesia on regional functional state of brain serotonin transporter (2010)
  • Author(s): Yamanaka, H., Onoe, K., Yokoyama, C., Onoe, H.
  • Organizer: PET study with[^<11> C] DASB in macaque monkeys. World Molecular Imaging Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2010-09-09
• [Presentation] プロポフォール麻酔は[^<11> C] DASBのセロトニントランスポーターへの結合を上昇させる:マカクザルを用いたPET研究 (2010)
  • Author(s): 山中創、尾上嘉代、横山ちひろ、尾上浩隆
  • Organizer: 日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] PETを用いた緑内障早期診断法の確立 (2010)
  • Author(s): 嶋澤雅光、井口勇太、伊藤保志、山中創、林拓也、季斌、樋口真人、須原哲也、今村一之、新家眞、渡辺恭良、尾上浩隆、原英彰
  • Organizer: 日本分子イメージング学会
  • Place of Presentation: 大津
  • Year and Date: 2010-05-22
• [Presentation] 小動物におけるモノアミントランスポーターPETイメージング (2010)
  • Author(s): 山中創
  • Organizer: 分子イメージング研究シンポジウム2010
  • Place of Presentation: 東京
  • Year and Date: 2010-01-22
• [Presentation] C^^<11>-Labeled cetrozole : a better PET tracer for aromatase (2009)
  • Author(s): Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X. L., Wada, Y., Takashima, T., Katayama, Y., Yamanaka, H., Suzuki, M., Onoe, H., Watanabe, Y.
  • Organizer: World Molecular Imaging Congress
  • Place of Presentation: Montreal
  • Year and Date: 2009-09-24
• [Presentation] 無麻酔下コモンマーモセットの[^<11> C] DASBによるPETイメージング:アカゲザルとの比較 (2009)
  • Author(s): 横山ちひろ、山中創、尾上嘉代、川崎章弘、長田浩子、白神恵子、土居久志、和田康弘、渡辺恭良、尾上浩隆
  • Organizer: 日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] 小動物用PETを用いたマカクサルおよびマーモセット脳における[^<11> C] DASB結合能 (2009)
  • Author(s): 山中創、横山ちひろ、長田浩子、土居久志、尾上嘉代、渡辺恭良、尾上浩隆
  • Organizer: 日本分子イメージング学会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-14