Identification of novel transporter genes involved in transport of nucleotide anticancer drugs
Project/Area Number |
21790530
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Applied pharmacology
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Research Institution | University of Niigata Prefecture |
Principal Investigator |
KAMLYAMA Shin 新潟県立大学, 人間生活学部, 助教 (70525401)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 輸送体 / SLC35 / 抗癌剤耐性 / 癌 / 増殖 / 遺伝子クローニング / 大腸癌 / 抗癌剤 / 遺伝子 / 薬剤反応性 |
Research Abstract |
SLC35F transporter family contains 6 member genes of unknownfunction. This study aimed to determine whether these genes are involved in sensitivity of cancer cells to nucleotide anticancer drugs. Silencing of these genes decreased cell growth of colon cancer cells ; however, that did not affect the sensitivity to 5fluorouracil. These results indicate that SLC35F members have no function on transport of nucleotide anticancer drugs in cancer cells.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Expression and role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma2011
Author(s)
Shin Kamiyama, Tomomi Ichimiya, Yuzuru Ikehara, Tomofumi Takase, Izumi Fujimoto, Takeshi Suda, Shoji Nakamori, Mitsuru Nakamura, Fumiaki Nakayama, Tatsuro Irimura, Hayao Nakanishi, Masahiko Watanabe, Hisashi Narimatsu, Shako Nishihara
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Journal Title
Glycobiology
Volume: 21(2)
Pages: 235-246
Related Report
Peer Reviewed