Assessment of the efficacy of collagen-coated-bead columns for antiplatelet therapy in clinical settings
| Project/Area Number |
21790532
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANEKO Makoto 東京大学, 医学部附属病院, 助教 (00377491)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血小板機能検査 / 抗血小板薬 / コラーゲンビーズカラム / 薬効モニタリング / 抗血小板剤 |
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| Research Abstract |
In this study, we evaluated the utility of 2 types of collagen-coated-bead columns in the assessment of platelet function associated with the efficacy of antiplatelet drug therapy and prediction of bleeding. In particular, platelet activity was measured to diagnose whether patients with thrombotic disease were drug resistant and to assess patients who were or were not administered antiplatelet agents before endoscopic biopsy.
Large variation in the platelet retention rate among healthy individuals was observed using the collagen-coated-bead column; this may reflect individual differences but not methodological variability. Overlapping of the retention rates of patients who were and were not administered the antiplatelet reagents may limit the establishment of reference intervals for platelet function in the present assay system. However, the platelet retention rate may reflect individual variability in response to the antiplatelet drugs and may be useful for monitoring the efficacy of antiplatelet therapy in the same individual. Thus, it is important to evaluate platelet function before and after medication for monitoring the effects of antiplatelet drugs. We also evaluated platelet function by using light-transmission platelet aggregometer and whole-blood aggregometer with a screen filtration pressure method. Platelet function assays are not interchangeable and may vary on the basis of the assay used. These findings suggest that the platelet function assay needs to be used in suitable methods and to be evaluated for additional verification of its clinical utility.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan2012
Author(s)
Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Niimi K, Yamamichi N, Kaneko M, Yatomi Y, Koike K.
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Journal Title
J Gastroenterol.
Volume: (Epub ahead of print)
NAID
Related Report
Peer Reviewed
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[Journal Article] Evaluation of safety of endoscopic biopsy without cessation of antithrom botic agents in Japan2012
Author(s)
Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Niimi K, Yamamichi N, Kaneko M, Yatomi Y, Koike K
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Journal Title
J Gastroenterol
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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[Presentation] 血小板・凝固検査2011
Author(s)
金子誠
Organizer
第9回日本検査血液学会 冬季セミナー
Place of Presentation
山梨県笛吹市石和町
Year and Date
2011-02-20
Related Report
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[Presentation] 血小板・凝固検査2011
Author(s)
金子誠
Organizer
第9回日本検査血液学会冬季セミナー
Place of Presentation
山梨県笛吹市石和町
Year and Date
2011-02-20
Related Report
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