Research for diagnosistic power and cost effectiveness of auto-antibody with data mining

• Project/Area Number: 21790534
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Kobe University
• Principal Investigator: NISHIMURA Kunihiro Kobe University, 大学院・医学研究科, 客員准教授 (70397834)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: メタアナリシス / データマイニング / 自己抗体 / 膠原病 / 費用効果分析 / 医療費 / データマインニング

Research Abstract

We showed the efficacy of the following serum markers; KL-6 and SP-D for interstitial pneumonia and beta-D glucan for fungal infection. Both of the diseases are very serious complications for the rheumatic diseases. We also proved significant relationship between Salazosulfapyridine, one of the common Disease Modifying Antirheumatic Drugs, and its side effect through the Single Nucleotide Polymorphism of its metabolic enzyme. These findings will be helpful to the diagnosis and treatment of the rheumatic diseases.

Research Products

• [Journal Article] Inhibitory effects of maternal smoking on the development of severe retinopathy of prematurity. (2011)
  • Author(s): Hirabayashi H, Honda S, Morioka I, Yokoyama N, Sugiyama D, Nishimura K, Matsuo M, Negi A.
  • Journal Title: Eye (Lond) 25(1) Pages: 123-4
• [Journal Article] Risk factors and mechanisms of fluoroquinolone resistance in 156 Escherichia coli strains clinically isolated from urinary tract infections. (2011)
  • Author(s): Yasufuku T, Shigemura K, Shirakawa T, Nakano Y, Tanaka K, Arakawa S, Kinoshita S, Nishimura K, Kawabata M, Fujisawa M
  • Journal Title: Scand J Infect Dis. 43(2) Pages: 83-8
  • Peer Reviewed
• [Journal Article] High Level of Plasma Adiponectin in Acute Stroke Patients isAssociated with Stroke Mortality. (2011)
  • Author(s): Nagasawa H, Yokota C, Toyoda K, Nishimura K, Ito A, Minematsu K
  • Journal Title: Journal of the Neurological Sciences 304(1-2) Pages: 102-6
  • Peer Reviewed
• [Journal Article] Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (2011)
  • Author(s): Kyogoku C, Yanagi M, Nishimura K, Sugiyama D, Morinobu A, Fukutake M, Maeda K, Shirakawa O, Kuno T, Kumagai S.
  • Journal Title: Psychiatry Res. Volume: 185 Pages: 16-19
  • Peer Reviewed
• [Journal Article] High Level of Plasma Adiponectin in Acute Stroke Patients isAssociated with Stroke Mortality. (2011)
  • Author(s): Nagasawa H, Yokota C, Toyoda K, Nishimura K, Ito A, Minematsu K
  • Journal Title: Journal of the Neurological Sciences Volume: 304(1-2) Pages: 102-106
  • Peer Reviewed
• [Journal Article] Risk factors and mechanisms of fluoroquinolone resistance in 156 Escherichia coli strains clinically isolated from urinary tract infections. (2011)
  • Author(s): Yasufuku T, Shigemura K, Shirakawa T, Nakano Y, Tanaka K, Arakawa S, Kinoshita S, Nishimura K, Kawabata M, Fujisawa M
  • Journal Title: Scand J Infect Dis. Volume: 43(2) Pages: 83-88
  • Peer Reviewed
• [Journal Article] Impact of smoking as a risk factor for developing rheumatoid arthritis : a meta-analysis of observational studies. (2010)
  • Author(s): Sugiyama D, Nishimura K, Tamaki K, Tsuji G, Nakazawa T, Morinobu A, Kumagai S.
  • Journal Title: Ann Rheum Dis 69巻 Pages: 70-81
  • Peer Reviewed
• [Journal Article] MicroRNA 499 as a Biomarker of Acute Myocardial Infarction. (2010)
  • Author(s): Adachi T, Nakanishi M, Otsuka Y, Nishimura K, Hirokawa G, Goto Y, Nonogi H, Iwai N
  • Journal Title: Clin Chem. 56(7)巻 Pages: 1183-5
  • Peer Reviewed
• [Journal Article] Association of four genetic loci with uric acid levels and reduced renal function : the J-SHIP Suita study (2010)
  • Author(s): Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y,Okamura T, Tomoike H, Iwai N, Miki T
  • Journal Title: Am J Nephrology 32(3) Pages: 279-86
  • Peer Reviewed
• [Journal Article] MicroRNA 499 as a Biomarker of Acute Myocardial Infarction. (2010)
  • Author(s): Adachi T, Nakanishi M, Otsuka Y, Nishimura K, Hirokawa G, Goto Y, Nonogi H, Iwai N
  • Journal Title: Clin Chem. Volume: 56(7) Pages: 1183-5
  • Peer Reviewed
• [Journal Article] Impact of smoking as a risk factor for developing rheumatoid arthritis : a meta-analysis of observational studies. (2010)
  • Author(s): Sugiyama D, Nishimura K, Tamaki K, Tsuji G, Nakazawa T, Morinobu A, Kumagai S.
  • Journal Title: Ann Rheum Dis. 69 Pages: 70-81
  • Peer Reviewed
• [Journal Article] Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. (2009)
  • Author(s): Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, Tokano Y, Mimori T, Terao C, Matsuda F, Kuno T, Kumagai S.
  • Journal Title: Mod Rheumatol. 19巻 Pages: 401-6
  • NAID: 10025113564
  • Peer Reviewed
• [Journal Article] MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. (2009)
  • Author(s): Nakamachi Y, Kawano S, Takenokuchi M, Nishimura K, Sakai Y, Chin T, Saura R, Kurosaka M, Kumagai S.
  • Journal Title: Arthritis Rheum 60巻 Pages: 1294-304
  • Peer Reviewed
• [Journal Article] Plasma tetrahydrobiopterin/dihydrobiopterin ratio : a possible marker of endothelial dysfunction. (2009)
  • Author(s): Takeda M, Yamashita T, Shinohara M, Sasaki N, Takaya T, Nakajima K, Inoue N, Masano T, Tawa H, Satomi-Kobayashi S, Toh R, Sugiyama D, Nishimura K, Yokoyama M, Hirata K, Kawashima S.
  • Journal Title: Circ J 73巻 Pages: 955-62
  • NAID: 10025930645
  • Peer Reviewed
• [Journal Article] Inhibitory effects of maternal smoking on the development of severe retinopathy of prematurity. (2009)
  • Author(s): Hirabayashi H, Honda S, Morioka I, Yokoyama N, Sugiyama D, Nishimura K, Matsuo M, Negi A.
  • Journal Title: Eye (Lond) (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. (2009)
  • Author(s): Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, Tokano Y, Mimori T, Terao C, Matsuda F, Kuno T, Kumagai S.
  • Journal Title: Mod Rheumatol. 19 Pages: 401-406
  • NAID: 10025113564
  • Peer Reviewed
• [Journal Article] MicroRNA-124a is a key regulator of proliferation and monocyte chemoa ttractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. (2009)
  • Author(s): Nakamachi Y, Kawano S, Takenokuchi M, Nishimura K, Sakai Y, Chin T, Saura R, Kurosaka M, Kumagai S.
  • Journal Title: Arthritis Rheum 60 Pages: 1294-1304
  • Peer Reviewed
• [Journal Article] Plasma tetrahydrobiopterin/dihydrobiopterin ratio : a possible marker of endothelial dysfunction. (2009)
  • Author(s): Takeda M, Yamashita T, Shinohara M, Sasaki N, Takaya T, Nakajima K, Inoue N, Masano T, Tawa H, Satomi-Kobayashi S, Toh R, Sugiyama D, Nishimura K, Yokoyama M, Hirata K, Kawashima S.
  • Journal Title: Circ J 73 Pages: 955-962
  • NAID: 10025930645
  • Peer Reviewed
• [Journal Article] Positive Association of Complement Factor H Gene Variants with the Effect of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy Clinical&Experimental Ophthalmology
  • Author(s): Bessho H, Honda S, Kondo H, Nishimura K, Negi A
  • Journal Title: in press
  • Peer Reviewed
• [Journal Article] Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population.
  • Author(s): Kyogoku C, Yanagi M, Nishimura K, Sugiyama D, Morinobu A, Fukutake M, Maeda K, Shirakawa O, Kuno T, Kumagai S.
  • Journal Title: Psychiatry Res. 185巻 Pages: 16-19
  • Peer Reviewed
• [Journal Article] Role of imaging studies in the diagnosis and evaluation of giant cell arteritis in Japanese : report of eight cases.
  • Author(s): Misaki K, Nishimura K, Sendo S, Miura N, Kawano S, Kumagai S.
  • Journal Title: Mod Rheumatol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Positive Association of Complement Factor H Gene Variants with the effect of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy
  • Author(s): Bessho H, Honda S, Kondo H, Nishimura K, Negi A
  • Journal Title: Clinical & Experimental Ophthalmology Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] The Oncogenic Phosphatase Wip1 is a Novel Prognostic Marker for Lung Adenocarcinoma Patient Survival
  • Author(s): Nishimura K, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Hurwitz J, Hayashi Y.
  • Journal Title: Cancer Sci Volume: (Epub ahead of print)
  • NAID: 10029294028
  • Peer Reviewed
• [Journal Article] Association of four genetic loci with uric acid levels and reduced renal function : the J-SHIP Suita study
  • Author(s): Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T
  • Journal Title: Am J Nephrology Volume: (In press)
  • Peer Reviewed
• [Presentation] 中大量ステロイド治療におけるビス剤の効果に関する研究(厚生労働省研究班追跡報告) (2010)
  • Author(s): 熊谷俊一、橋本博史、田中良哉、杉山大典、西村邦宏、河野誠司
  • Organizer: 第54回日本リウマチ学会総会・学術集会/第19回国際リウマチシンポジウム
  • Place of Presentation: 神戸
• [Presentation] 中大量ステロイド治療におけるビス剤の効果に関する研究(厚生労働省研究班追跡報告) (2010)
  • Author(s): 熊谷俊一、橋本博史、田中良哉、杉山大典、西村邦宏、河野誠司
  • Organizer: 第54回日本リウマチ学会総会・学術集会/第19回国際リウマチシンポジウム
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
• [Presentation] 頭頸部癌に対するsequential therapyの臨床的および免疫組織学的検討 (2010)
  • Author(s): 伴野真哉(愛知医科大学 耳鼻咽喉科), 小川徹也, 池田篤彦, 西村邦宏, 土屋吉正, 佐野順司, 横井豊治, 植田広海
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] 疫学学習のための、二変量正規分布の差のベイズ推測動的視覚化ツールの開発 (2009)
  • Author(s): 井上弘樹, 柳澤振一郎, 西村邦宏
  • Organizer: 第68回日本公衆衛生学会総会
  • Place of Presentation: 奈良県文化会館(奈良県)
  • Year and Date: 2009-10-21
• [Presentation] 医学判断における、二つの割合の評価のためのベイズ推測視覚化システム (2009)
  • Author(s): 井上弘樹, 内山八郎, 柳澤振一郎, 西村邦宏
  • Organizer: 第25回日本健康科学学会
  • Place of Presentation: 東京体育館(東京都)
  • Year and Date: 2009-08-29
• [Presentation] 膠原病患者における低カルボキシル化オステオカルシンの測定 (2009)
  • Author(s): 杉山大典, 西村邦宏, 三枝淳, 杉本健, 河野誠司, 森信暁雄, 熊谷俊一
  • Organizer: 第56回日本臨床検査医学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2009-08-28
• [Presentation] 関節リウマチ特異的マイクロRNAの病態解析 (2009)
  • Author(s): 中町祐司, 河野誠司, 野口依子, 大藪智奈美, 炬口真理子, 西村邦宏, 熊谷俊一
  • Organizer: 第56回日本臨床検査医学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2009-08-28
• [Presentation] 超幾何分布のベイズ推測視覚化ツールの開発と精度管理への応用に対する検討 (2009)
  • Author(s): 井上弘樹, 内山八郎, 西村邦宏, 柳澤振一郎
  • Organizer: 第56回日本臨床検査医学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2009-08-28
• [Presentation] 脈派伝導速度による妊娠、出産の動脈硬化に対する防護作用の検討 (2009)
  • Author(s): 西村邦宏, 杉山大典, 橋本正良, 秋田穂束, 河野誠司, 森信暁雄, 熊谷俊一
  • Organizer: 第56回日本臨床検査医学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2009-08-27
• [Presentation] RAの病因・病態 miR-124aはRA滑膜細胞で細胞増殖とMCP1分泌を調整する (2009)
  • Author(s): 中町祐司, 河野誠司, 西村邦宏, 酒井良忠, 佐浦隆一, 黒坂昌弘, 熊谷俊一
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2009-04-23
• [Presentation] RAの病因・病態miR-124はRA滑膜細胞で細胞増殖とMCP1分泌を調整する (2009)
  • Author(s): 中町祐司, 河野誠司, 西村邦宏, 酒井良忠, 佐浦隆一, 黒坂昌弘, 熊谷俊一
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都)
  • Year and Date: 2009-04-23
• [Book] CRESP 企画運営委員会臨床研究の方法論とマネジメント (2009)
  • Author(s): 西村邦宏、熊谷俊一
  • Total Pages: 242
  • Publisher: 神戸大学大学院医学研究科
• [Book] 臨床研究の方法論とマネジメント (2009)
  • Author(s): 西村邦宏、熊谷俊一
  • Total Pages: 242
  • Publisher: 神戸大学大学院医学研究科CRESP企画運営委員会
• [Remarks] ホームページ等