The efficacy of identifying the stem cell to decide the breast cancer treatment strategy.

• Project/Area Number: 21790536
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Okayama University
• Principal Investigator: SHIEN Tadahiko Okayama University, 病院, 助教 (30509451)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 乳癌 / 幹細胞 / 予後因子 / がん幹細胞 / 転移

Research Abstract

(1) The expression of ALDH1 which is the marker of the breast cancer stem cell in the axillary lymph node metastasis was the significantly prognostic factor for node positive (n=1-3) breast cancer patients.
(2) There was not significantly correlation between the expression of ALDH1 in distant metastatic lesion and prognosis. Because of the discordances of predictive factors between primary and metastatic lesions, the pathological examinations in metastases are important to decide the treatment strategy of metastatic breast cancer.

Research Products

• [Presentation] Prognostic impact of discordance of biological markers between primary and metastatic breast cancer tissue from autopsy. (2011)
  • Author(s): 野上智弘、枝園忠彦
  • Organizer: International Conference on Primary Therapy of Early breast Cancer 2011.
  • Place of Presentation: スイス ザンクトガレン
  • Year and Date: 2011-03-17
• [Presentation] Prognostic impact of discordance of biological markers between primary and metastatic breast cancer tissue from autopsy. (2011)
  • Author(s): 野上智弘、枝園忠彦
  • Organizer: International Conference on Primary Therapy of Early breast Cancer 2011
  • Place of Presentation: St.Gallen,スイス
  • Year and Date: 2011-03-17
• [Presentation] Clinical features of surgical resection for solitary pulmonary metastasis and the discrepancy in immunopathological features between primary and metastatic breast cancer lesions (2010)
  • Author(s): 枝園忠彦
  • Organizer: San Antonio Breast Cancer Symposium 2010
  • Place of Presentation: アメリカ サンアントニオ
  • Year and Date: 2010-12-10
• [Presentation] Clinical features of surgical resection for solitary pulmonary metastasis and the discrepancy in immunopathological features between primary and metastatic breast cancer lesions (2010)
  • Author(s): 枝園忠彦
  • Organizer: SanAntonio Breast Cancer Symposium 2010
  • Place of Presentation: SanAntonio,アメリカ
  • Year and Date: 2010-12-10
• [Presentation] Expression of ALDH1 in the axillary lumph node metastases is a predictor of poor clinical outcome in breast cancer patients. (2010)
  • Author(s): 野上智弘, 枝園忠彦
  • Organizer: ASCO Breast Cancer Symposium 2010
  • Place of Presentation: アメリカ ワシントンDC
  • Year and Date: 2010-10-01
• [Presentation] Expression of ALDH1 in the axillary lumph node metastases is a predictor of poor clinical outcome in breast cancer patients. (2010)
  • Author(s): 野上智弘、枝園忠彦
  • Organizer: ASCO Breast Cancer Symposium 2010
  • Place of Presentation: Washington DC,アメリカ
  • Year and Date: 2010-10-01
• [Presentation] 乳癌肺転移に対する切除例の検討 (2010)
  • Author(s): 野上智弘、枝園忠彦
  • Organizer: 第7回日本乳癌学会中国四国地方会
  • Place of Presentation: 高知
  • Year and Date: 2010-09-25
• [Presentation] 乳癌肺転移に対する切除例の検討 (2010)
  • Author(s): 野上智弘、枝園忠彦
  • Organizer: 第7回 日本乳癌学会 中国四国地方会
  • Place of Presentation: 高知県高知市
  • Year and Date: 2010-09-25
• [Presentation] 乳癌ALDH1陽性腋窩リンパ節転移と予後の相関 (2010)
  • Author(s): 野上智弘、枝園忠彦
  • Organizer: 第18回日本乳癌学会学術総会
  • Place of Presentation: 北海道
  • Year and Date: 2010-06-25
• [Presentation] 乳癌ALDH1陽性腋窩リンパ節転移と予後の相関 (2010)
  • Author(s): 野上智弘、枝園忠彦
  • Organizer: 第18回 日本乳癌学会学術総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2010-06-25