Basic study of plasma CTGF as a useful biomarker for hypertensive cardiac hypertrophy

• Project/Area Number: 21790537
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Okayama University
• Principal Investigator: SHINOHATA Ryoko Okayama University, 大学院・保健学研究科, 助教 (70335587)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: CTGF / 心肥大 / 高血圧 / バイオマーカー

Research Abstract

I studied the association of serum (or plasma) CTGF levels with progression of cardiac hypertrophy in experimentally pressure-overloaded (PO) rats. The CTGF levels were increased in some rats within 2 weeks after operation without left ventricular hypertrophy, but no statistical significant difference was found between the PO and the sham groups. There were significant increases in left ventricular wall thickness of the PO rats after the third week of the operation, but the CTGF levels were similar between the two groups.