| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
The tyrosine kinase Syk (molecular weight 72KDa) which is widely expressed in hematopoietic and non-hematopoietic cells has been reported as a key molecule which is associated with hematopoiesis of the B cell lineage. We noticed the role of Syk in leukemic progression of myeloid lineage and established the differentiative model in neutrophil and Syk mutant cell lines using 32D (mouse AML cell lines). As a result, we suggested that Syk was not associated with the differentiation of myeloid lineage, but high expression of Syk SH2 domain was related to the suppression of differentiation.
|
