| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In this study, we performed search for genotype-phenotype associations in consecutive autopsies of elderly Japanese population, focusing on human CAR polymorphisms and various diseases. We found that several SNPs in NR1I3 gene were significantly associated with reduce or increase risk of the diseases, after adjustment. We provide data that polymorphisms of CAR, which controls the metabolism and elimination of endogenous and exogenous toxic compound or drugs, may play an important role in the development of the diseases. However, further prospective studies with large sample sizes are required to confirm our observations.
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