Basic study for clinical application of the biomarkers for insecticide exposure
| Project/Area Number |
21790551
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
UEYAMA Jun Nagoya University, 医学部・保健学科, 助教 (00397465)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 農薬 / 殺虫剤 / バイオモニタリング / 有機リン系殺虫剤 / ピレスロイド系殺虫剤 / ジアルキルリン酸類 / 3フェノキシ安息香酸 / UDPグルクロン酸転移酵素 / 環境化学物質 / βグルクロニダーゼ活性 / バイオマーカー / 殺虫剤撒布職域従事者 / 尿中殺虫剤代謝物 / コリンエステラーゼ / ガスクロマトグラフ質量分析 / カルボキシルエステラーゼ |
|---|
| Research Abstract |
Urinary pyrethroid (PYR) metabolites, e.g. 3-phenoxybenzoic acid (3-PBA), and organophosphorus insecticide (OP) metabolites, e.g. dialkylphosphate (DAP), have been used as the most sensitive biomarker for environmental PYR and OP exposure since the late 1990s. The objective is to clarify the fundamental characteristics of urinary OP and PYR metabolite for the practical usage. Our study had three major findings. First, the most salient findings are the distribution of urinary DAP concentrations in Japanese non- and occupational OP exposure workers, suggesting that the urinary DAP concentrations in Japanese workers were approximately at the same or lower levels than those in other countries. Second, there was seasonal differences of urinary DAP concentrations (summer > winter). Third, PYR metabolite, 3-PBA, excretion was decreased by co-exposure of OP due to part in carboxylesterase inhibition.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Comparison of urinary concentrations of 3-phenoxybenzoic acid among general residents in rural and suburban areas and employees of pest control firms2009
Author(s)
Kimata A, Kondo T, Ueyama J, Yamamoto K, Yoshitake J, Takagi K, Suzuki K, Inoue T, Ito Y, Hamajima N, Kamijima M, Gotoh M, Shibata E.
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Journal Title
Int Arch Occup Environ Health 82
Pages: 1173-1178
Related Report
Peer Reviewed
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[Journal Article] Broken Sperm, Cytoplasmic Droplets and Reduced Sperm Motility Are Principal Markers of Decreased Sperm Quality Due to Organophosphorus Pesticides in Rats2009
Author(s)
Okamura A, Kamijima M, Ohtani K, Yamanoshita O, Nakamura D, Ito Y, Miyata M, Ueyama J, Suzuki T, Imai R, Takagi K, Nakajima T.
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Journal Title
J Occup Health 51
Pages: 478-487
NAID
Related Report
Peer Reviewed
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[Presentation] 浜島信之非喫煙成人女性での尿中コチニン値と受動喫煙との関連2010
Author(s)
喜田優人, 近藤高明, 田中哲也, 中川優子, 木下香織, 鈴木麻予, 服部由花, 一ノ谷英憲, 木全明子, 上山純, 森田えみ, 田村高志, 栗木砂家加, 冨田耕太郎, 岡田理恵子, 川合紗世, 菱田朝陽, 内藤真理子, 若井建志
Organizer
第56回東海公衆衛生学会学術大会
Place of Presentation
岐阜県岐阜市
Year and Date
2010-07-24
Related Report
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[Presentation] 非喫煙成人女性での尿中コチニン値と受動喫煙との関連2010
Author(s)
喜田優人, 近藤高明, 田中哲也, 中川優子, 木下香織, 鈴木麻予, 服部由花, 一ノ谷英憲, 木全明子, 上山純, 森田えみ, 田村高志, 栗木砂家加, 冨田耕太郎, 岡田理恵子, 川合紗世, 菱田朝陽, 内藤真理子, 若井建志, 浜島信之
Organizer
第56回東海公衆衛生学会学術大会
Place of Presentation
岐阜県岐阜市
Year and Date
2010-07-24
Related Report
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[Presentation] 有機リン系殺虫剤曝露によるヒト血漿中β-グルクロニダーゼ活性値の変化2010
Author(s)
上山純, 佐藤哲男, 近藤高明, 高木健次, 柴田英治, 五藤雅博, 木全明子, 斎藤勲, 長谷川高明, 涌澤伸哉, 上島通浩
Organizer
第30回日本中毒学会西日本部会
Place of Presentation
岐阜
Year and Date
2010-02-26
Related Report
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[Book] 日本臨床2010
Author(s)
上島通博、上山純、高木健次、柴田英治
Total Pages
4
Publisher
日本臨床社
Related Report
