Molecular analysis of anti-proliferative effects against cancer cells treated with phytochemicals derived from cruciferous vegetables for development of novel molecular-targeting combinatory strategy for cancer prevention
| Project/Area Number |
21790556
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YOGOSAWA Shingo Kyoto Prefectural University of Medicine, 医学研究科, 助教 (70381936)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌予防 / 食品成分 / アブラナ科植物 / 細胞増殖抑制 / 細胞周期停止 / アポトーシス / オートファジー / 活性酸素種 / インドール-3-カルビノール |
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| Research Abstract |
To achieve desirable effects of dietary phytochemicals on cancer prevention, studies on effective combinations of phytochemicals and the molecular mechanisms might contribute to chemopreventive strategies. This study shows the anti-proliferative effects of components of the cruciferous vegetables believed to be useful for cancer prevention. In addition, combinations of indole-3-carbinol, one component of cruciferous vegetables, with genistein contained in soy or galangin contained in propolis were also shown to be effective for inhibition of growth of cancer cells accompanied with inhibition of autophagic process or accumulation of reactive oxygen species (ROS), respectively.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Histone deacetylase inhibitors and 15-deoxy-Δ^<12,14>-prostaglandin J_2 synergistically induce apoptosis.2010
Author(s)
Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T.
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Journal Title
Clinical Cancer Research. 16
Pages: 2320-2332
Related Report
Peer Reviewed
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[Journal Article] Histone deacetylase inhibitors and 15-deoxy^-Δ^<12,14>-prostaglandin J_2 synergistically induce apoptosis.2010
Author(s)
Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T.
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Journal Title
Clin Cancer Res.
Volume: 16
Pages: 2320-2332
Related Report
Peer Reviewed
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[Presentation] Histone deacetylase inhibitors and 15-deoxy-Δ^<12,14>-prostaglandin J_2 synergistically induce apoptosis.2010
Author(s)
Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T.
Organizer
AACR 101^<st> Annual Meeting 2010
Place of Presentation
Walter E.Washington Convention Center.
Year and Date
2010-04-21
Related Report
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[Presentation] Histone deacetylase inhibitors and 15-deoxy^-Δ^<12,14>-prostaglandin J_2 synergistically induce apoptosis.2010
Author(s)
Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T.
Organizer
AACR 101^<st> Annual Meeting 2010
Place of Presentation
Walter E.Washington Convention Center
Year and Date
2010-04-21
Related Report
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