The absorption and metabolism of arsenic species in intestinal and tubular epithelial cells.
| Project/Area Number |
21790558
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
HATA Akihisa Chiba Institute of Science, 危機管理学部, 助手 (10433690)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | arsenic / speciation / biological monitoring / seafood / occupational exposure / urine / renal tubule / bioloical monitoring / well water / creatinine adjusted |
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| Research Abstract |
MDCK cells and Caco-2 cells did not alter the chemical form of arsenate, arsenite, monomethylarsonic acid, dimethylarsinic acid, trimethylarsine oxide, arsenocholine, and arsenobetaine. The permeability of these 7 arsenic species was studied in a renal tubular epithelial model comprising MDCK monolayer, and was found to be 1-2.5-times higher than that of creatinine. The arsenic compounds in fish and seaweeds were effectively extracted using 50% methanol (extractant) and bead-beating tube (physical extraction method).
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Report
(3 results)
Research Products
(5 results)
