| Project/Area Number |
21790560
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
|
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| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
NISHITAI Gen The Institute of Physical and Chemical Research, 自然免疫研究チーム, 研究員 (60509941)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
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| Keywords | 衛生 / 癌 / 細胞・組織 / シグナル伝達 / 免疫学 |
|---|
| Research Abstract |
Cadmium has been classified as a human carcinogen by the International Agency for Research on Cancer. However, the molecular link between cadmium exposure and carcinogenesis is unclear. In this study, we found that matrix metalloproteinase (MMP) 9 and MMP13 were accumulated in mouse embryonic stem (ES) cells treated with CdCl_2. MMPs contribute to many steps in the carcinogenic process, including angiogenesis and metastasis. Cadmium-induced MMP9 and MMP13 expression was abolished in ES cells deficient in the activation of JNK, a member of the mitogen-activated protein kinases, suggesting that cadmium-induced MMP expression is mediated by JNK signaling pathway.
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