Molecule epidemiology research on genetic polymorphisms of DNA repair enzyme and colorectal cancer
| Project/Area Number |
21790584
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | Nagoya University (2010)
Kyushu University (2009) |
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Principal Investigator |
YIN Guang Nagoya University, 医学系研究科, 特任助教 (90444786)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 大腸がん / DNA修復酵素遺伝子多型 / 分子疫学 / 症例対照研究 |
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| Research Abstract |
On the analysis of polymorphisms of single strand break repair enzyme XRCC1 gene (Arg194Trp, Arg280His, and Arg399Gln) and colorectal cancer risk, the399Gln/Gln genotype was associated with an increased risk of colorectal cancer, and the increased risk was more remarkable in individuals with these genotype and high alcohol consumption. XRCC3 Thr241Met and XRCC4 which are double strand-break repair enzyme gene polymorphism were also examined. The interaction of these gene polymorphisms and alcohol consumption for colorectal cancer risk was shown. The above result has suggested that DNA repair enzyme gene polymorphisms has played the role important for colorectal carcinogenesis in relation to alcohol consumption.
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Report
(3 results)
Research Products
(2 results)
