| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
It is thought that the longevity genes suppresses the appearance of the carcinoma cell by controlling aging. On the other hand, even the ape whose it is primates that appearance by the individual increases because calorie retriction is confirmed as for the longevity genes. Then, carcinogen (methylcholanthrene ; MCA) was administered in mice restricted calorie. However, there was no difference in the free feeding group with the crowd that had done the calorie restriction. Then, a similar experiment was done with the II type diabetic model mouse (ob/ob and db/db mouse) thought that the receptivity of the calorie restriction or more was high. As a result, clear carcinogenesis frequency was controlled in the calorie limitation food group compared with the free feeding group. It was one side, and there was no significant difference in the blood sugar level. Next, the cell strain of the carcinoma cell (Lewis lung carcinoma and B16F0) was transplanted to this II type diabetic model mouse, and it observed it. As for the calorie restrcited group, the development of tumors was intentionally controlled compared with the free feeding group. It was one side, and neither the blood sugar level, the amount of the insulin secretion nor the GLP-1 value had a significant difference.
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