The mechanism of prevention of vascular senescence by Sirtuin
Project/Area Number |
21790621
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | The University of Tokyo |
Principal Investigator |
OTA Hidetaka The University of Tokyo, 医学部附属病院, 特任臨床医 (20431869)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | SIRT1 / eNOS / 抗老化 / 血管老化 / Sirt1 / 血管障害 / 血管内皮細胞老化 / 老化抑制作用 |
Research Abstract |
Our results indicated that cilostazol or statins exerted protective effects against endothelial senescence and dysfunction, and enhancement of NO production is a key mediator in up-regulation of SIRT1.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway.2010
Author(s)
Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
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Journal Title
Arterioscler Thromb Vasc Biol. 30(11)
Pages: 2205-2211
Related Report
Peer Reviewed
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[Presentation] SIRT1/eNOS axis inhibits vascular senescence, dysfunction and atherosclerosis.2010
Author(s)
Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
Organizer
ISHR 2010
Place of Presentation
kyoto, Japan
Year and Date
2010-05-15
Related Report
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