The mechanism of prevention of vascular senescence by Sirtuin

• Project/Area Number: 21790621
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: OTA Hidetaka The University of Tokyo, 医学部附属病院, 特任臨床医 (20431869)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: SIRT1 / eNOS / 抗老化 / 血管老化 / Sirt1 / 血管障害 / 血管内皮細胞老化 / 老化抑制作用

Research Abstract

Our results indicated that cilostazol or statins exerted protective effects against endothelial senescence and dysfunction, and enhancement of NO production is a key mediator in up-regulation of SIRT1.

Research Products

• [Journal Article] Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway. (2010)
  • Author(s): Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: Arterioscler Thromb Vasc Biol. 30(11) Pages: 2205-2211
  • Peer Reviewed
• [Journal Article] SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. (2010)
  • Author(s): Ota H, Eto M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: J Atheroscler Thromb. 17(5) Pages: 431-435
  • Peer Reviewed
• [Journal Article] Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway. (2010)
  • Author(s): Ota H
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 30(11) Pages: 2205-11
  • Peer Reviewed
• [Journal Article] SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis (2010)
  • Author(s): Ota H
  • Journal Title: J Atheroscler Thromb. Volume: 17(5) Pages: 431-5
  • Peer Reviewed
• [Journal Article] 長寿遺伝子Sirt1について (2010)
  • Author(s): 大田秀隆
  • Journal Title: 日医会誌 Volume: 47(1) Pages: 11-16
• [Journal Article] SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis (2010)
  • Author(s): Ota H, Eto M, Ogawa S, Iijima K, Akishita M, Ouchi Y.
  • Journal Title: J Atheroscler Thromb. (in press)
  • Peer Reviewed
• [Journal Article] Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors (2010)
  • Author(s): Iijima K, Hashimoto H, Ota H, et al.
  • Journal Title: Atherosclerosis (in press)
  • Peer Reviewed
• [Journal Article] Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation : therapeutic implication of cilostazol after drug-eluting stent implantation. (2009)
  • Author(s): Ota H, Eto M, Ako J, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Journal Title: J Am Coll Cardiol. 53(24) Pages: 2298-2305
  • Peer Reviewed
• [Journal Article] Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation : therapeutic implication of cilostazol after drug-eluting stent implantation (2009)
  • Author(s): Ota H, Eto M, Ako J, Ogawa S, Iijima K, Akishita M, Ouchi Y.
  • Journal Title: J Am Coll Cardiol 53 Pages: 2298-305
  • Peer Reviewed
• [Presentation] SIRT1/eNOS axis inhibits vascular senescence, dysfunction and atherosclerosis. (2010)
  • Author(s): Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y
  • Organizer: ISHR 2010
  • Place of Presentation: kyoto, Japan
  • Year and Date: 2010-05-15
• [Presentation] シンポジウム14「血管のアンチエイジング-血管から老いないために」スタチンによる血管老化抑制機構 (2010)
  • Author(s): 大田秀隆
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] スタチンによる血管老化抑制機構 (2010)
  • Author(s): 大田秀隆
  • Organizer: 日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] ヒト内皮細胞における酸化ストレス誘発性早期老化のシロスタゾールによるSirt1上方制御を介した抑制 (2009)
  • Author(s): 大田秀隆, 江頭正人, 他5名
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 山口