oriental medicine has an effect on cancer : Molecular Pathological investigation about antitumor effect of Juzen-taiho-to

• Project/Area Number: 21790624
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kitasato University (2010-2011); University of Toyama (2009)
• Principal Investigator: TAKAHASHI Hiroyuki 北里大学, 医学部, 講師 (60377330)
• Co-Investigator(Renkei-kenkyūsha): TAKANO Yasuo 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター, 臨床研究所, 所長 (60142022)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 十全大補湯 / 抗腫瘍効果 / 抗癌剤 / SV40トランスジェニックマウス / SV40トランスジェニックマウ

Research Abstract

It was elucidated that Juzen-taiho-to had no influence on gene expression of tumor itself and no direct antitumor effect. But it was clarified that Juzen-taiho-to induced the production of proteins for phylaxis and enzymes for drug metabolism without hepatotoxicity.

Research Products

• [Journal Article] Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis (2011)
  • Author(s): Takahashi H, Wang JP, Zheng HC, Masuda S, Takano Y.
  • Journal Title: Histol Histopathol Volume: 26 Pages: 663-71
• [Journal Article] Parafibromin expression is an independent prognostic factor for colorectal carcinomas (2011)
  • Author(s): Zheng HC, Wei ZL, Xu XY, Nie XC, Yang X, Takahashi H, Takano Y.
  • Journal Title: Hum Pathol Volume: 42 Pages: 1089-102
• [Journal Article] The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas (2011)
  • Author(s): Zheng HC, Xia P, Xu XY, Takahashi H, Takano Y.
  • Journal Title: Hum Pathol Volume: 42 Pages: 424-33
• [Journal Article] Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis (2011)
  • Author(s): Takahashi H, Wang JP, Zheng HC, Masuda S, Takano Y
  • Journal Title: Histol Histopathol Volume: 26 Pages: 663-671
  • Peer Reviewed
• [Journal Article] The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas (2011)
  • Author(s): Zheng HC, Xia P, Xu XY, Takahashi H, Takano Y
  • Journal Title: Hum Pathol Volume: 42 Pages: 424-433
  • Peer Reviewed
• [Journal Article] Parafibromin expression is an independent prognostic factor for colorectal carcinomas (2011)
  • Author(s): Zheng HC, Wei ZL, Xu XY, Nie XC, Yang X, Takahashi H, Takano Y
  • Journal Title: Hum Pathol Volume: 42 Pages: 1089-1102
  • Peer Reviewed
• [Journal Article] Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas. (2010)
  • Author(s): Zheng HC, Xu XY, Xing YN, Wei ZL, Takahashi, H, Masuda S, Takano Y.
  • Journal Title: Hum Pathol. Volume: 41 Pages: 724-736
  • Peer Reviewed
• [Journal Article] The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes. (2010)
  • Author(s): Zheng HC, Zheng YS, Xia P, Xu XY, Xing YN, Takahashi H, Guan YF, Takano Y.
  • Journal Title: Histol Histopathol. Volume: 25 Pages: 445-452
  • Peer Reviewed
• [Journal Article] The screening of viral risk factors in tongue and pharyngolaryngeal squamous carcinoma. (2010)
  • Author(s): Zheng Y, Xia P, Zheng HC, Takahashi H, Masuda S, Takano Y.
  • Journal Title: Anticancer Res. Volume: 30 Pages: 1233-1238
  • Peer Reviewed
• [Journal Article] The role of Reg IV gene and its encoding product in gastric carcino genesis. (2010)
  • Author(s): Zheng HC, Xu,XY, Yu M, Takahashi H, Masuda S, Takano Y.
  • Journal Title: Hum Pathol. 41 Pages: 59-69
  • Peer Reviewed
• [Journal Article] REG IV overexpression in an early stage of colorectal carcinogenesis : An immunohistochemical study. (2010)
  • Author(s): Li XH, Zheng Y, Zheng HC, Takahashi H, Yang XH, Masuda S, Takano Y.
  • Journal Title: Histol Histopathol. 25 Pages: 473-484
  • Peer Reviewed
• [Journal Article] SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice. (2009)
  • Author(s): Zheng HC, Nakamura T, Zheng Y, Nakanishi Y, Tabuchi Y, Uchiyama A, Takahashi H, Takano Y.
  • Journal Title: J Cancer Res Clin Oncol. 135 Pages: 1521-1532
  • Peer Reviewed
• [Journal Article] PTEN expression and mutation in colorectal carcinomas. (2009)
  • Author(s): Li XH, Zheng HC, Takahashi H, Masuda S, Yang XH, Takano Y.
  • Journal Title: Oncol Rep. 22 Pages: 757-764
  • Peer Reviewed
• [Presentation] 難治性黄疸の原因と考えられた総胆管peribiliary cystの一剖検例 (2010)
  • Author(s): 高橋博之, 三輪重治, 野本一博, 林伸一, 常山幸一, 高野康雄
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 難治性黄疸の原因と考えられた総胆管peribiliary cystの一剖検例 (2010)
  • Author(s): 高橋博之, 三輪重治, 野本一博, 林伸一, 常山幸一, 高野康雄
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] The roles of ING5 during colorectal carcinogenesis and subsequent progression. (2010)
  • Author(s): Zheng Huachuan, 高橋博之, 高野康雄
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 鋸歯状ポリープ-腺癌経路を示唆する癌と臨床病理学的事項の関係の検討 (2009)
  • Author(s): 高橋博之, 中嶋隆彦, 藤本誠, 三輪重治, 野本一博, 林伸一, 常山幸一, 高野康雄
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] Lipomatous myofibroblastomaの1例 (2009)
  • Author(s): 野本一博, 中西ゆう子, 三輪重治, 高橋博之, 林伸一, 常山幸一, 高野康雄
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 自然発症肥満・糖尿病モデル(TSOD)マウスの肝病変NAFLD/NASHモデルとしての有用性. (2009)
  • Author(s): 常山幸一, 藤本誠, 野本一博, 高橋博之, 林伸一, 三輪重治, 高野康雄
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都