| Project/Area Number |
21790627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kochi University |
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Principal Investigator |
SHIMIZU Takahiro Kochi University, 教育研究部医療学系, 助教 (00363276)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 中枢性交感神経ー副腎髄質系 / ホスホリパーゼC / ジアシルグリセロールリパーゼ / 2-アラキドノイルグリセロール / モノアシルグリセロールリパーゼ / アラキドン酸 / 脳内大麻 / エンドカンナビノイド / カンナビノイドCB受容体 / 中枢性交感神経-副腎髄質系 / カンナビノドCB受容体 / 2-アラキドノイルグリセロール(2-AG) / ストレス反応 / 交感神経-副腎髄質系 / カテコールアミン / 高速液体クロマトグラフィー / コルチコトロピン放出因子(CRF) |
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| Research Abstract |
We examined the roles of brain endocannabinoid (eCB) in regulation of central activation of sympatho-adrenomedullary (SA) outflow using anesthetized rats. 2-Arachidonoylglycerol (2-AG), an eCB, was endogenously generated in the brain during the central activation of SA outflow. This 2-AG played a promotional role as a precursor of arachidonic acid and also an inhibitory role as an eCB in the activation. These findings suggest that brain 2-AG has bidirectional roles in the central activation of SA outflow. Taken together, brain eCB can be a beneficial target for therapeutic drugs to modulate the outflow.
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