Role of COX and NOS in the presympathetic PVN neurons in restraint stress-induced sympathetic activation

• Project/Area Number: 21790628
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: University of Tsukuba
• Principal Investigator: YAMAGUCHI Naoko University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (50380324)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ストレス / シクロオキシゲナーゼ / 一酸化窒素合成酵素 / CRF / 視床下部室傍核 / 交感神経系 / 交感神経-副腎髄質系

Research Abstract

Stress is one of the important factors to activate the sympathetic nervous system. In this study, I investigated whether brain COX and NOS can mediate restraint stress-induced sympathetic activation in rats. The present results suggest that COX-1, COX-2 and inducible NOS, but not neuronal NOS, in the presympathetic PVN neurons mediate acute restraint stress-induced sympathetic activation.

Research Products

• [Journal Article] Cyclooxygenase and nitric oxide synthase in the presympathetic neurons in the paraventricular hypothalamic nucleus are involved in restraint stress-induced sympathetic activation in rats. (2010)
  • Author(s): Yamaguchi N, Ogawa S, Okada S
  • Journal Title: Neuroscience 170 Pages: 773-781
  • Peer Reviewed
• [Journal Article] α1-Adrenoceptor activation is involved in the central N-methyl-D-aspartateinduced adrenomedullary outflow in rats. (2010)
  • Author(s): Okada S, Yamaguchi N
  • Journal Title: Eur.J.Pharmacol. 640 Pages: 55-62
  • Peer Reviewed
• [Journal Article] Cyclooxygenase and nitric oxide synthase in the presympathetic neurons in the paraventricular hypothalamic nucleus are involved in restraint stress-induced sympathetic activation in rats (2010)
  • Author(s): Yamaguchi, et al.
  • Journal Title: Neuroscience Volume: 170 Pages: 773-781
  • Peer Reviewed
• [Journal Article] α1-Adrenoceptor activation is involved in the central N-methyl-D-aspartate-induced adrenomedullary outflow in rats (2010)
  • Author(s): Okada, Yamaguchi
  • Journal Title: European Journal of Pharmacology Volume: 640 Pages: 55-62
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-1 and -2 in spinally projecting neurons are involved in CRF-induced sympathetic activation. (2009)
  • Author(s): Yamaguchi N, Okada S
  • Journal Title: Auton.Neurosci. 151 Pages: 82-89
  • Peer Reviewed
• [Journal Article] Nitric oxide synthase isozymes in spinally projecting PVN neurons are involved in CRF-induced sympathetic activation. (2009)
  • Author(s): Yamaguchi N, Okada S, Usui D, Yokotani K
  • Journal Title: Auton.Neurosci. 148 Pages: 83-89
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-1 and -2 in spinally projecting neurons are involved in CRF-induced sympathetic activation (2009)
  • Author(s): Yamaguchi, Okada
  • Journal Title: Autonomic Neuroscience 151 Pages: 82-89
  • Peer Reviewed
• [Journal Article] Nitric oxide synthase isozymes in spinally projecting PVN neurons are involved in CRF-induced sympathetic activation (2009)
  • Author(s): Yamaguchi, et al.
  • Journal Title: Autonomic Neuroscience 148 Pages: 83-89
  • Peer Reviewed
• [Presentation] Role of oxytocin receptor in the regulation of social recognition in mice (2010)
  • Author(s): Yamaguchi N, Tsuda MC, Sagoshi S, Nishimori K, Sakamoto T, Ogawa S
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸市
• [Presentation] Brain cyclooxygenase and nitric oxide synthase are involved in restraint stress-induced neuronal activation of spinally projecting (2009)
  • Author(s): Yamaguchi, et al.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-17
• [Presentation] 脳室内投与CRFによる交感神経-副腎髄質系賦活における脳内アドレナリン作動性受容体の役割 (2009)
  • Author(s): Okada S, Yamaguchi N
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: 和歌山市
• [Presentation] Brain cyclooxygenase and nitric oxide synthase are involved in restraint stress-induced neuronal activation of spinally projecting neurons in rats (2009)
  • Author(s): Yamaguchi N, Okada S
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋市
• [Presentation] Role of brain inflammatory mediators in the restraint stress-induced elevation of plasma catecholamines (2009)
  • Author(s): Okada S, Yamaguchi N
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋市