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Role of COX and NOS in the presympathetic PVN neurons in restraint stress-induced sympathetic activation

Research Project

Project/Area Number 21790628
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of Tsukuba

Principal Investigator

YAMAGUCHI Naoko  University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (50380324)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsストレス / シクロオキシゲナーゼ / 一酸化窒素合成酵素 / CRF / 視床下部室傍核 / 交感神経系 / 交感神経-副腎髄質系
Research Abstract

Stress is one of the important factors to activate the sympathetic nervous system. In this study, I investigated whether brain COX and NOS can mediate restraint stress-induced sympathetic activation in rats. The present results suggest that COX-1, COX-2 and inducible NOS, but not neuronal NOS, in the presympathetic PVN neurons mediate acute restraint stress-induced sympathetic activation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (5 results)

  • [Journal Article] Cyclooxygenase and nitric oxide synthase in the presympathetic neurons in the paraventricular hypothalamic nucleus are involved in restraint stress-induced sympathetic activation in rats.2010

    • Author(s)
      Yamaguchi N, Ogawa S, Okada S
    • Journal Title

      Neuroscience 170

      Pages: 773-781

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] α1-Adrenoceptor activation is involved in the central N-methyl-D-aspartateinduced adrenomedullary outflow in rats.2010

    • Author(s)
      Okada S, Yamaguchi N
    • Journal Title

      Eur.J.Pharmacol. 640

      Pages: 55-62

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase and nitric oxide synthase in the presympathetic neurons in the paraventricular hypothalamic nucleus are involved in restraint stress-induced sympathetic activation in rats2010

    • Author(s)
      Yamaguchi, et al.
    • Journal Title

      Neuroscience

      Volume: 170 Pages: 773-781

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α1-Adrenoceptor activation is involved in the central N-methyl-D-aspartate-induced adrenomedullary outflow in rats2010

    • Author(s)
      Okada, Yamaguchi
    • Journal Title

      European Journal of Pharmacology

      Volume: 640 Pages: 55-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-1 and -2 in spinally projecting neurons are involved in CRF-induced sympathetic activation.2009

    • Author(s)
      Yamaguchi N, Okada S
    • Journal Title

      Auton.Neurosci. 151

      Pages: 82-89

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide synthase isozymes in spinally projecting PVN neurons are involved in CRF-induced sympathetic activation.2009

    • Author(s)
      Yamaguchi N, Okada S, Usui D, Yokotani K
    • Journal Title

      Auton.Neurosci. 148

      Pages: 83-89

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-1 and -2 in spinally projecting neurons are involved in CRF-induced sympathetic activation2009

    • Author(s)
      Yamaguchi, Okada
    • Journal Title

      Autonomic Neuroscience 151

      Pages: 82-89

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide synthase isozymes in spinally projecting PVN neurons are involved in CRF-induced sympathetic activation2009

    • Author(s)
      Yamaguchi, et al.
    • Journal Title

      Autonomic Neuroscience 148

      Pages: 83-89

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of oxytocin receptor in the regulation of social recognition in mice2010

    • Author(s)
      Yamaguchi N, Tsuda MC, Sagoshi S, Nishimori K, Sakamoto T, Ogawa S
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸市
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Brain cyclooxygenase and nitric oxide synthase are involved in restraint stress-induced neuronal activation of spinally projecting2009

    • Author(s)
      Yamaguchi, et al.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳室内投与CRFによる交感神経-副腎髄質系賦活における脳内アドレナリン作動性受容体の役割2009

    • Author(s)
      Okada S, Yamaguchi N
    • Organizer
      第62回日本自律神経学会総会
    • Place of Presentation
      和歌山市
    • Related Report
      2010 Final Research Report
  • [Presentation] Brain cyclooxygenase and nitric oxide synthase are involved in restraint stress-induced neuronal activation of spinally projecting neurons in rats2009

    • Author(s)
      Yamaguchi N, Okada S
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of brain inflammatory mediators in the restraint stress-induced elevation of plasma catecholamines2009

    • Author(s)
      Okada S, Yamaguchi N
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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