| Project/Area Number |
21790629
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagoya City University |
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Principal Investigator |
KITO Yoshihiko Nagoya City University, 大学院・医学研究科, 助教 (60381787)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 東洋医学 / 炎症性腸疾患 / 漢方薬 / 平滑筋 / 自発活動 / 結腸 / カハールの介在細胞 |
|---|
| Research Abstract |
Hange-shashin-to (TJ-14) and Keishi-ka-shakuyaku-to (TJ-60) inhibited the generation of spontaneous contractions of circular muscles in the rat distal colon. The production of nitric oxide was partially involved in those inhibitory effects. TJ-14 also inhibited atropine-sensitive contractions induced by transmural nerve stimulation (TNS), suggesting that TJ-14 seems to be effective in severe diarrhea in ulcerative colitis or Crohn disease. On the other hand, TJ-60 showed weak inhibitory effect on atropine-sensitive contractions induced by TNS. Thus, TJ-60 may be effective in irritable bowel syndrome, which causes recurring diarrhea and/or constipation in association with abdominal pain.
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