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Development of novel alternative approach for liver cirrhosis therapy using adipose-derived stem cells

Research Project

Project/Area Number 21790633
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTokyo Medical University

Principal Investigator

MIYAZAKI Teruo  東京医科大学, 医学部, 助教 (60532687)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords代替医療 / 肝硬変 / 脂肪組織由来肝細胞 / 骨格筋 / 脂肪由来性幹細胞
Research Abstract

The purpose in the present study was to investigate the effectiveness of adipose-derived stem cell(ADSC) transplantation into skeletal muscle as novel alternative therapy for liver cirrhosis in mouse. Human ADSC was transplanted into the gastrocnemius muscle in nude mouse, and then, the mouse received the repetitional injections of CCl_4 to induce liver damage and fibrosis. In the ADSC-transplanted mice, serum levels of albumin and total protein were kept at higher than in the control mice. Spleen index(tissue weight/body weight) were significantly lower in the ADSC mice than the control, and other skeletal muscle weights per body weight were also maintained in the ADSC mice. The protein expression of alpha-smooth muscle actin as a parameter of fibrosis was also lower in the ADSC mice than the control. The present study suggested a possibility that the transplantation of ADSC into skeletal muscle would be one of novel strategies for alternative therapy to the patients with liver cirrhosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010

All Journal Article (1 results) Presentation (5 results)

  • [Journal Article] The role of taurine on the skeletal muscle cell differentiation2012

    • Author(s)
      Miyazaki T, Akira Honda A, Ikegami T, Matsuzaki Y.
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Presentation] The role of taurine on the skeletal muscle cell differentiation2012

    • Author(s)
      Miyazaki T, Honda A, Ikegami T, Matsuzaki Y.
    • Organizer
      18th international taurine meeting
    • Place of Presentation
      Marrakech, Morocco
    • Related Report
      2011 Final Research Report
  • [Presentation] カルシウムシグナリングを介したタウリンの筋線維芽細胞分化作用2011

    • Author(s)
      宮崎照雄
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関市
    • Related Report
      2011 Final Research Report
  • [Presentation] The effect of taurine treatment on the differentiation of cultured skeletal muscle cell2011

    • Author(s)
      Miyazaki T, Honda A, Ikegami T, Shirai M, Miyakawa S, Matsuzaki Y.
    • Organizer
      The 12th International Congress on Amino Acids, Peptides and Proteins
    • Place of Presentation
      Beijing, China
    • Related Report
      2011 Final Research Report
  • [Presentation] The augmentative action of taurine on the differentiation of C2C12 cells to myotube2011

    • Author(s)
      Miyazaki T, Honda A, Ikegami T, Shirai M, Miyakawa S, Matsuzaki Y.
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] タウリンの骨格筋細胞分化増強作用2010

    • Author(s)
      宮崎照雄, 宮川俊平
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      市川市
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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