| Project/Area Number |
21790634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Musashino University |
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Principal Investigator |
SHIMADA Tsutomu Musashino University, 薬学研究所, 講師 (90409384)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Kaempferia parviflora / TSOD / 3T3-L1細胞 / 脂肪蓄積抑制効果 / 脂肪分化促進作用 / 脂肪細胞分化誘導効果 / ポリメトキシフラボノイド / PPARγ / CEBPβ / GATA-2 |
|---|
| Research Abstract |
Kaempferia parviflora (KP), a Zingiberaceae plant, showed the preventive effects on metabolic diseases, including anti-obesity and improvement of insulin-resistance in spontaneously obese type II diabetic mice. Polymethoxylflavones, included in KP, enhanced the differentiation of adipocytes in vitro, suggesting that KP directly affected to adipocytes and improved insulin-resistance. In is concluded that KP is promising as a seed compound for developing therapeutic medicines or food for specified health use (FOSHU) for metabolic diseases.
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