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The study of amino acids imbalance which influences the immune cells, especially dendritic cells, in patients with advanced cirrhosis.

Research Project

Project/Area Number 21790643
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

KAKAZU Eiji  Tohoku University, 病院, 医員 (20509377)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords肝硬変 / 分岐鎖アミノ酸 / アミノ酸 / 単球 / 非代償性肝硬変 / xCT / 酸化ストレス / 樹状細胞 / mTOR
Research Abstract

We analyzed the function of myeloid dendritic cells using a serum free culture medium consistent with the average concentration of plasma amino acids from healthy controls or advanced cirrhotic patients to reflect more closely the actual environment of the living body. Elevating the extracellular concentration of BCAAs improved the maturation of dendritic cells in patients with advanced cirrhosis. Elevating the extracellular concentration of BCAAs seems to be beneficial for improving the functions of dendritic cells in advanced cirrhotic patients.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 9 results) Presentation (6 results)

  • [Journal Article] Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-γ secretion activity.2011

    • Author(s)
      Kondo Y, Ueno Y, Kakazu E, Kobayashi K, Shiina M, Tamai K, Machida K, Inoue J, Wakui Y, Fukushima K, Obara N, Kimura O, Shimosegawa T.
    • Journal Title

      J Gastroenterol. 46(2)

      Pages: 232-241

    • NAID

      10029027386

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines.2010

    • Author(s)
      Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, Fukushima K, Shiina M, Yamagiwa Y, Kondo Y, Inoue J, Kakazu E, Iwasaki T, Kawagishi N, Shimosegawa T, Sugamura K.
    • Journal Title

      Cancer Sci 101

      Pages: 2145-2155

    • NAID

      10027832222

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes.2010

    • Author(s)
      Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, Inoue J, Tamai K, Wakui Y, Tanaka Y, Ninomiya M, Obara N, Fukushima K, Ishii M, Kobayashi T, Niitsuma H, Kon S, Shimosegawa T.
    • Journal Title

      J Infect Dis 202

      Pages: 202-213

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肝硬変患者の免疫機構に関与する遊離アミノ酸の研究2010

    • Author(s)
      嘉数英二
    • Journal Title

      東北医学会雑誌 122巻

      Pages: 30-32

    • Related Report
      2010 Final Research Report
  • [Journal Article] Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.2010

    • Author(s)
      Obara N, Fukushima K, Ueno Y, Wakui Y, Kimura O, Tamai K, Kakazu E, Inoue J, Kondo Y, Ogawa N, Sato K, Tsuduki T, Ishida K, Shimosegawa T.
    • Journal Title

      J Hepatol 53

      Pages: 326-334

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.2010

    • Author(s)
      Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K.
    • Journal Title

      Biochem Biophys Res Commun 399

      Pages: 384-390

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-gamma ligand2010

    • Author(s)
      Wakui Y, Inoue J, Ueno Y, Fukushima K, Kondo Y, Kakazu E, Obara N, Kimura O, Shimosegawa T.
    • Journal Title

      rosiglitazone.Biochem Biophys Res Commun 396

      Pages: 508-514

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肝硬変患者の免疫機構に関与する遊離アミノ酸の研究2010

    • Author(s)
      嘉数英二
    • Journal Title

      東北医学会雑誌

      Volume: 122巻 Pages: 30-32

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis.2009

    • Author(s)
      Kakazu E, Ueno Y, Kondo Y, Fukushima K, Shiina M, Inoue J, Tamai K, Ninomiya M, Shimosegawa T.
    • Journal Title

      Hepatology 50

      Pages: 1936-1945

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan.2009

    • Author(s)
      Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T.
    • Journal Title

      J Gastroenterol 44

      Pages: 329-337

    • NAID

      10025174367

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肝硬変でのアミノ酸代謝異常が樹状細胞に与える影響2009

    • Author(s)
      嘉数英二, 上野義之, 菅野記豊, 下瀬川徹
    • Journal Title

      肝・胆・膵 58巻2号

      Pages: 247-254

    • Related Report
      2010 Final Research Report
  • [Journal Article] 非代償性肝硬変で出現する血漿アミノ酸imbalanceは樹状細胞成熟化を抑制し2009

    • Author(s)
      嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
    • Journal Title

      分岐鎖アミノ酸(BCAA)により改善する「薬理と治療」 VOL 37

      Pages: 93-98

    • Related Report
      2010 Final Research Report
  • [Journal Article] 非代償性肝硬変におけるアミノ酸imbalanceが免疫機構に及ぼす影響2009

    • Author(s)
      嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
    • Journal Title

      消化器科 Vol.49 No.2

      Pages: 190-196

    • Related Report
      2010 Final Research Report
  • [Journal Article] Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis2009

    • Author(s)
      Kakazu E, Ueno Y, Kondo Y, Fukushima K, Shiina M, Inoue J, Tamai K, Ninomiya M, Shimosegawa T.
    • Journal Title

      Hepatology 50

      Pages: 1936-1945

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝硬変でのアミノ酸代謝異常が樹状細胞に与える影響2009

    • Author(s)
      嘉数英二, 上野義之, 菅野記豊, 下瀬川徹
    • Journal Title

      肝・胆・膵 58

      Pages: 247-254

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 非代償性肝硬変で出現する血漿アミノ酸 imbalance は樹状細胞成熟化を抑制し、分岐鎖アミノ酸(BCAA)により改善する2009

    • Author(s)
      嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
    • Journal Title

      薬理と治療 37

      Pages: 93-96

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 非代償性肝硬変におけるアミノ酸 imbalance が免疫機構に及ぼす影響2009

    • Author(s)
      嘉数英二, 上野義之, 近藤泰輝, 下瀬川徹
    • Journal Title

      消化器科 49

      Pages: 190-196

    • Related Report
      2009 Annual Research Report
  • [Presentation] L-CystineはLPS刺激時の単球からのTNF-α産生を高め、非代償性肝硬変の腎機能低下に関与する2010

    • Author(s)
      嘉数英二
    • Organizer
      第18回日本消化器病関連学会週間
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] L-cystineはLPS刺激時の単球からのTNF-α産生を高め2010

    • Author(s)
      嘉数英二, 上野義之, 近藤泰輝, 福島耕治, 井上淳, 二宮匡史, 涌井祐太, 岩崎隆雄, 下瀬川徹
    • Organizer
      非代償性肝硬変の腎機能低下に関与するJDDW
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Branched-chain amino acids improve the maturation of dendritic cells in patients with advanced cirrhosis ex vivo.2010

    • Author(s)
      EIJI KAKAZU, YOSHIYUKI UENO, YASUTERU KONDO, KOJI FUKUSHIMA, MASAAKI SHIINA YOKO YAMAGIWA, JUN INOUE, KEIICHI TAMAI, NORIYUKI OBARA, OSAMU KIMURA, YUTA WAKUI TOORU SHIMOSEGAWA
    • Organizer
      APASL
    • Place of Presentation
      北京
    • Related Report
      2010 Final Research Report
  • [Presentation] An imbalance in plasma amino acids of advaced cirrhotic patients impairs the maturation of dendritic cells via mTOR/S6K signaling pathway.2010

    • Author(s)
      EIJI KAKAZU, YOSHIYUKI UENO, YASUTERU KONDO, KOJI FUKUSHIMA, MASAAKI SHIINA, YOKO YAMAGIWA, JUN INOUE, KEIICHI TAMAI, TOORU SHIMOSEGAWA
    • Organizer
      APASL
    • Place of Presentation
      香港
    • Related Report
      2010 Final Research Report
  • [Presentation] 分岐鎖アミノ酸(BCAA)の樹状細胞成熟化に対する影響とBCAA製剤内服後の血行動態が末梢血単核球に与える影響について2009

    • Author(s)
      嘉数英二, 上野義之, 近藤泰輝, 福島耕治, 山極洋子, 椎名正明, 井上淳, 玉井恵一, 二宮匡史 城戸治, 中込悠, 小原範之, 木村修, 涌井祐太, 岩崎隆雄, 下瀬川徹
    • Organizer
      肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 非代償性肝硬変のアミノ酸インバランスが樹状細胞成熟化に及ぼす影響について2009

    • Author(s)
      嘉数英二
    • Organizer
      肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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