TNFSF15 derived from T cells may play an important role in the pathogenesis of Crohn's disease.
| Project/Area Number |
21790644
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
KAKUTA Yoichi Tohoku University, 大学院・医学系研究科, 非常勤講師 (50509205)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 炎症性腸疾患 / 感受性遺伝子 / TNFSF15 / クローン病 |
|---|
| Research Abstract |
We analyzed the transcriptional mechanisms of TL1A induced by LPS using the human monocytic cell line U937, LPS induces TL1A expression through the transcriptional activation via a NF-kappa B pathway. The NF-kappa B binding site in the 5' flanking region of TL1A was identified.
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Report
(3 results)
Research Products
(11 results)
