TNFSF15 derived from T cells may play an important role in the pathogenesis of Crohn's disease.

• Project/Area Number: 21790644
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: KAKUTA Yoichi Tohoku University, 大学院・医学系研究科, 非常勤講師 (50509205)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 炎症性腸疾患 / 感受性遺伝子 / TNFSF15 / クローン病

Research Abstract

We analyzed the transcriptional mechanisms of TL1A induced by LPS using the human monocytic cell line U937, LPS induces TL1A expression through the transcriptional activation via a NF-kappa B pathway. The NF-kappa B binding site in the 5' flanking region of TL1A was identified.

Research Products

• [Journal Article] Involvement of NF-kappa B pathway in TL1A gene expression induced by lipopolysaccharide (2010)
  • Author(s): Katsuya Endo, Yoshitaka Kinouchi, Yoichi Kakuta, Nobuo Ueki, Seiichi Takahashi, Tooru Shimosegawa
  • Journal Title: Cytokine 49 Pages: 215-220
  • Peer Reviewed
• [Journal Article] 炎症性腸疾患への今日的アプローチ・病因・病態生理-遺伝子異常面からみた (2010)
  • Author(s): 角田洋一、木内喜孝、高橋成一、下瀬川徹
  • Journal Title: 成人病と生活習慣病 Vol40 No12 Pages: 1351-1356
• [Journal Article] 炎症性腸疾患への今日的アプローチ-病因・病態生理-遺伝子異常面からみた (2010)
  • Author(s): 角田洋一、木内喜孝、高橋成一、下瀬川徹
  • Journal Title: 成人病と生活習慣病 Volume: 40(12) Pages: 1351-1356
• [Journal Article] 消化器領域における遺伝子多型検査 (2009)
  • Author(s): 角田洋一, 木内喜孝, 遠藤克哉, 根来健一, 高橋成一, 下瀬川徹
  • Journal Title: 分子消化器病 6(4) Pages: 370-374
• [Journal Article] クローン病感受性遺伝子TNFSF15遺伝子多型における機能解析 (2009)
  • Author(s): 角田洋一、木内喜孝、植木紳夫、遠藤克哉、根来健一、高橋成一、下瀬川徹
  • Journal Title: 東北医学会雑誌 121 Pages: 59-61
  • NAID: 10026082877
• [Presentation] Functional analysis of the candidate genes associated with Japanese IBD (2010)
  • Author(s): Yoichi Kakuta, Yoshitaka Kinouchi, Seiichi Takahashi, Tooru Shimosegawa
  • Organizer: The Kinshukai International Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] The IL12B gene is associated with the clinical course of Crohn's disease in Japanese patients. (2010)
  • Author(s): Yoichi Kakuta, Yoshitaka Kinouchi, 他10名
  • Organizer: 18th UEGW
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-10-27
• [Presentation] The IL12B gene is associated with the clinical course of Crohn's disease in Japanese patients. (2010)
  • Author(s): Yoichi Kakuta, Yoshitaka Kinouchi, Hisashi Shiga, Katsuya Endo, Seiichi Takahashi, Tooru Shimosegawa
  • Organizer: 18^<th> United European Gastroenterology Week
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-10-25
• [Presentation] 日本人クローン病感受性候補遺伝子TNFSF15, HLA-DQB1, IL12Bと再燃率との関連について (2010)
  • Author(s): 角田洋一、木内喜孝, 他10名
  • Organizer: JDDW
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 日本人クローン病感受性候補遺伝子TNFSF15,HLA-DQB1,IL12Bと再燃率との関連について (2010)
  • Author(s): 角田洋一、木内喜孝、志賀永嗣、遠藤克哉、根来健一、高橋成一、下瀬川徹
  • Organizer: 第52回 日本消化器病学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] Functional analysis of the candidate genes associated with inflammatory bowel disease using allelic expression imbalance analysis (2010)
  • Author(s): Yoichi Kakuta, Yoshitaka Kinouchi, Seiichi Takahashi, Tooru Shimosegawa
  • Organizer: US-Japan GI Executive meeting
  • Place of Presentation: 東京
  • Year and Date: 2010-06-18