A comprehensive analysis of pancreatitis associated CNVs to establish a screening method

• Project/Area Number: 21790646
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: KUME Kiyoshi Tohoku University, 大学院・医学系研究科, 非常勤講師 (30431563)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 膵炎 / 遺伝子異常

Research Abstract

The aim of this study was to investigate the association of trypsinogen copy number mutations with pancreatitis in Japan. None of 230 Japanese patients with chronic pancreatitis and 180 patients with acute pancreatitis had this mutation. This copy number mutation might be rare in Japan.

Research Products

• [Journal Article] Genetic background is different between sentinel and recurrent acute pancreatitis. (2011)
  • Author(s): 正宗淳、有賀啓之、粂潔, ほか4名
  • Journal Title: J Gastroenterol Hepatol. 印刷中
  • Peer Reviewed
• [Journal Article] Genetic background is different between sentinel and recurrent acute pancreatitis. (2011)
  • Author(s): Masamune A, Ariga H, Kume K, et al.
  • Journal Title: J Gastroenterol Hepatol Volume: (未定 印刷中)
  • Peer Reviewed
• [Journal Article] -651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan. (2010)
  • Author(s): 正宗淳、粂潔、菊田和宏, ほか8名
  • Journal Title: J Gastroenterol. 45巻 Pages: 225-233
  • NAID: 10027214689
  • Peer Reviewed
• [Journal Article] 遺伝子異常と膵炎の発症 (2010)
  • Author(s): 粂潔、下瀬川徹
  • Journal Title: HUMAN SCIENCE 21巻 Pages: 22-25
• [Journal Article] 慢性膵炎と膵癌 (2010)
  • Author(s): 粂潔、正宗淳、菅野敦, ほか7名
  • Journal Title: 肝胆膵画像 12巻 Pages: 215-222
• [Journal Article] 家族性膵疾患とそのアプローチ (2010)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Journal Title: 成人病と生活習慣病 40巻 Pages: 69-73
• [Journal Article] -651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan. (2010)
  • Author(s): Masamune A, Kume K, et al.
  • Journal Title: J Gastroenterol Volume: 45 Pages: 225-233
  • NAID: 10027214689
  • Peer Reviewed
• [Journal Article] Microsatellite polymorphism in intron 2 of human Toll-like recept or 2 gene is associated with susceptibility to acute pancreatitis in Japan. (2009)
  • Author(s): 高木康彦、正宗淳、粂潔, ほか6名
  • Journal Title: Hum Immunol 70巻 Pages: 200-204
  • Peer Reviewed
• [Journal Article] A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders. (2009)
  • Author(s): 粂潔、正宗淳、高木康彦, ほか7名
  • Journal Title: GUT 58巻 Pages: 820-824
  • Peer Reviewed
• [Journal Article] 膵癌危険因子としてのSPINK1遺伝子変異 (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Journal Title: 消化器科 49巻 Pages: 533-537
• [Journal Article] 膵癌危険因子としてのSPINK1遺伝子変異 (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Journal Title: THE GIFOREFRONT 5巻 Pages: 89-91
• [Journal Article] 遺伝子異常は膵炎とどうかかわるのか (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Journal Title: 分子消化器病 6巻 Pages: 219-225
• [Journal Article] 急性膵炎と修飾する遺伝子異常 (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Journal Title: 肝・胆・膵 59 Pages: 173-179
• [Journal Article] 成因別特徴(膵石症の頻度・分布)遺伝性膵炎 (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Journal Title: 肝・胆・膵 58巻 Pages: 467-475
• [Journal Article] 膵臓疾患の分子機構 (2009)
  • Author(s): 下瀬川徹、粂潔、濱田晋
  • Journal Title: 臨床消化器内科 24巻 Pages: 239-238
• [Journal Article] A loss-of-function p.G191R variant in the anionic trypsinogen(PRSS2)gene in Japanese patients with pancreatic disorders (2009)
  • Author(s): Kume K, et al
  • Journal Title: Gut 58 Pages: 820-824
  • Peer Reviewed
• [Journal Article] Chronic pancreatitis and pancreatic cancer : prediction and mechanism (2009)
  • Author(s): Shimosegawa T, et al
  • Journal Title: Clin Gastroenterol Hepatol 7
  • Peer Reviewed
• [Presentation] Measurement of serum PSTI level might be useful to detect IVS3+2T>C (c.194+2T>C) mutation in the SPINK1 gene (2010)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Organizer: United European Gastroenterology Week
  • Place of Presentation: Barcelona、Spain
  • Year and Date: 2010-10-26
• [Presentation] Measurement of serum PSTI level might be useful to detect IVS3+2T>C(c.194+2T>C) mutation in the SPINK1 gene (2010)
  • Author(s): Kume K, et al.
  • Organizer: 18th UEGW 2010
  • Place of Presentation: Spain Barcelona
  • Year and Date: 2010-10-26
• [Presentation] 膵炎リスクとしてのアルコールと遺伝的要因 (2010)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Organizer: 日本アルコール・薬物医学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-08
• [Presentation] Genetic background of chronic pancreatitis in Japan (2010)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Organizer: 国際膵臓学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-07-13
• [Presentation] Chymotrypsin C gene variations in Japanese patients with Chronic Pancreatitis (2010)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Organizer: 国際膵臓学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-07-12
• [Presentation] 慢性膵炎における遺伝子異常 (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Organizer: 日本膵臓学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-31
• [Presentation] 慢性膵炎における遺伝子変異 (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Organizer: 第40回日本膵臓学会大会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-31
• [Book] 遺伝子変異による機能異常と膵炎(第94回日本消化器病学会総会記念誌) (2009)
  • Author(s): 粂潔、正宗淳、下瀬川徹
  • Publisher: 財団法人日本消化器病学会
• [Book] Annual Review 2009消化器 (2009)
  • Author(s): 粂潔
  • Publisher: 中外医学社
• [Remarks] ホームページ等