Peptidomics analysis of serum in patients with pancreatic cancer

• Project/Area Number: 21790658
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Mie University
• Principal Investigator: YAMAMOTO Norihiko 三重大学, 医学部附属病院, 助教 (60501963)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 膵癌 / バイオマーカー / ペプチド / プロテオミクス / 質量分析計

Research Abstract

We have found many fragments of peptides that determine the development of pancreatic cancer. Among them, we identified and focused on increase or decrease of the special fragments. These findings are very useful for the diagnosis of pancreatic cancers. These molecules would be the promising molecular target of diagnosis and therapy.

Research Products

• [Journal Article] Seven cases of autoimmune hepatitis that developed after drug-induced liver injury (2011)
  • Author(s): Sugimoto K, Ito T, Yamamoto N, Shiraki K
  • Journal Title: Hepatology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Up-regulation of Glypican-3 in Human Hepatocellular Carcinoma (2010)
  • Author(s): Suzuki M, Sugimoto K, Tanaka J, Tameda M, Inagaki Y, Kusagawa S, Nojiri K, Beppu T, Yoneda K, Yamamoto N, Ito M, Yoneda M, UchidaK, Takase K, Shiraki K.
  • Journal Title: Anticancer Volume: 30 Pages: 5055-61
  • Peer Reviewed
• [Journal Article] Functional cell surface expression of Toll-like receptor 9 promotes cell proliferation and survival inhuman hepatocellular carcinomas (2010)
  • Author(s): Tanaka J, Sugimoto K, Shiraki K, Tameda M, Kusagawa S, Nojiri K, Beppu T, Yoneda K, Yamamoto N, Uchida K, Kojima T, Takei Y.
  • Journal Title: Int J Oncol Volume: 37 Pages: 805-14
  • Peer Reviewed
• [Journal Article] Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation (2010)
  • Author(s): Beppu T, Sugimoto K, Shiraki K, Tameda M, Kusagawa S, Nojiri K, Tanaka J, Yamamoto N, Takei Y, Takaki H, Uraki J, Nakatsuka A, Yamakado K, Takeda K.
  • Journal Title: Int J Mol Med Volume: 26 Pages: 425-33
  • Peer Reviewed
• [Journal Article] Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System (2010)
  • Author(s): Ooi K, Sugimoto K, Shiraki K, Yamamoto N, Tameda M, Beppu T, Tanaka J, Nojiri K, Kusagawa S, Takei Y, Masuda C, Nobori T.
  • Journal Title: Int J Mol Med Volume: 25 Pages: 601-6
  • Peer Reviewed
• [Journal Article] Subphrenic versus nonsubphrenic hepatocellular carcinoma : combined therapy with chemoembolization and radiofrequency ablation (2010)
  • Author(s): Yamakado K, Nakatsuka A, Takaki H, Sakurai H, Isaji S, Yamamoto N, Shiraki K, Takeda K.
  • Journal Title: AJR Am J Roentgenol Volume: 194 Pages: 530-5
  • Peer Reviewed