Clarification of pathogenesis for primary sclerosing cholangitis

• Project/Area Number: 21790659
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: UEDA Yoshihide Kyoto University, 医学研究科, 講師 (90378662)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 原発性硬化性胆管炎 / 肝移植 / 再発

Research Abstract

Blood-relative donor and cytomegalovirus infection were identified as risk factors for recurrence of primary sclerosing cholangitis after living donor liver transplantation, suggesting that both genetic factor and environmental factor are important for pathogenesis of primary sclerosing cholangitis.

Research Products

• [Journal Article] Tsubouchi H: Risk Factors for Recurrence of Primary Sclerosing Cholangitis after Living Donor Liver Transplantation in Japanese Registry. (2011)
  • Author(s): Egawa H, Ueda Y, Ichida T, Teramukai S, Nakanuma Y, Onishi S
  • Journal Title: Am J Transplant 11 Pages: 518-527
  • Peer Reviewed
• [Journal Article] Risk Factors for Recurrence of Primary Sclerosing Cholangitis after Living Donor Liver Transplantation in Japanese Registry. (2011)
  • Author(s): Egawa H, Ueda Y, Ichida T, Teramukai S, Nakanuma Y, Onishi S, Tsubouchi H.
  • Journal Title: American Journal of Transplantation Volume: 11 Pages: 518-527
  • Peer Reviewed
• [Journal Article] Uemoto S: Risk factors for recurrence of primary sclerosing cholangitis after living donor liver transplantation : a single center experience. (2009)
  • Author(s): Egawa H, Taira K, Teramukai S, Haga H, Ueda Y, Yonezawa A, Masuda S, Tsuji H, Ashihara E, Takada Y
  • Journal Title: Dig Dis Sci 54 Pages: 518-527
  • Peer Reviewed
• [Journal Article] Risk factors for recurrence of primary sclerosing cholangitis after living donor liver transplantation : a single center experience. (2009)
  • Author(s): Egawa H, Taira K, Teramukai S, Haga H, Ueda Y, Yonezawa A, Masuda S, Tsuji H, Ashihara E, Takada Y, Uemoto S
  • Journal Title: Dig Dis Sci. 54 Pages: 1347-1354
  • Peer Reviewed
• [Journal Article] Nakanuma Y: Frequent overlap of active hepatitis in recurrent primary sclerosing cholangitis after living donor liver transplantation relates to its rapidly progressive course.
  • Author(s): Miyagawa-Hayashino A, Egawa H, Yoshizawa A, Ueda Y, Ichida T, Ueno Y, Uemoto S, Harada K
  • Journal Title: Hum Pathol (in press)
  • Peer Reviewed
• [Journal Article] Frequent overlap of active hepatitis in recurrent primary sclerosing cholangitis after living donor liver transplantation relates to its rapidly progressive course.
  • Author(s): Miyagawa-Hayashino A, Egawa H, Yoshizawa A, Ueda Y, Ichida T, Ueno Y, Uemoto S, Harada K, Nakanuma Y.
  • Journal Title: Human Pathology Volume: (in press)
  • Peer Reviewed
• [Presentation] 内科医からみた各臓器移植の適応条件成人生体肝移植の適応決定における問題点 (2010)
  • Author(s): 上田佳秀、上本伸二、千葉勉
  • Organizer: 第46回日本移植学会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-21
• [Presentation] 自己免疫性肝胆道系疾患に対する肝移植症例の検討 (2010)
  • Author(s): 吉澤淳、上田佳秀、上本伸二
  • Organizer: JDDW2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 原発性硬化性胆管炎に対する生体肝移植全国調査報告 (2010)
  • Author(s): 江川裕人、上田佳秀、市田隆文、手良向聡、上本伸二、中沼安二、坪内博仁
  • Organizer: JDDW2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 原発性硬化性胆管炎に対する生体肝移植全国調査報告 (2010)
  • Author(s): 江川裕人、上田佳秀、市田隆文、手良向聡、上本伸二、中沼安二、坪内博仁
  • Organizer: 第28回日本肝移植研究会
  • Place of Presentation: 広島
  • Year and Date: 2010-07-01
• [Presentation] 本邦における原発性硬化性胆管炎の肝移植後長期成績:再発の現状と危険因子に関する多施設共同研究 (2010)
  • Author(s): 江川裕人、上田佳秀、市田隆文
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-28
• [Presentation] 京都大学におけるPSCに対する肝移植の経験 (2009)
  • Author(s): 上田佳秀
  • Organizer: 第27回日本肝移植研究会
  • Place of Presentation: 静岡
  • Year and Date: 2009-07-11
• [Presentation] 京都大学におけるPSCに対する肝移植の経験 (2009)
  • Author(s): 上田佳秀
  • Organizer: 第27回日本肝移植研究会
  • Place of Presentation: 静岡県三島市
  • Year and Date: 2009-07-11