WT1-specific immunological assessments in WT1-peptide-based cancer vaccine in combination with gemcitabine for patients with advanced pancreatic cancer

• Project/Area Number: 21790665
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: NISHIDA Sumiyuki 大阪大学, 大学院・医学系研究科, 寄附講座助教 (00403189)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 胆道学 / 膵臓学(膵臓癌) / 膵臓癌 / WT1 / 癌免疫療法 / 細胞傷害性リンパ球 / 細胞障害性リンパ球

Research Abstract

A clinical study of WT1-peptide-based cancer vaccine(WT1 vaccine) in combination with gemcitabine was performed for the patients with advanced pancreatic cancer. I focused on the association between clinical efficiency and WT1-specific immunological monitoring, such as i) delayed-type hypersensitivity(DTH) to WT1 peptide and ii) WT1-specific cytotoxic lymphocytes in the peripheral blood(WT1-CTLs). An association between longer survival and DTH-positivity was statistically significant, and longer survivors had higher frequency of WT1-CTLs with memory phenotype.

Research Products

• [Journal Article] Vaccination with WT-1 (Wilms' Tumor gene-1) peptide and BCG-CWS in melanoma (2012)
  • Author(s): Nishioka M, Tanemura A, Nishida S, et al
  • Journal Title: Eur J Dermatol
  • Peer Reviewed
• [Journal Article] WT1 Peptide Therapy for a Patient with Chemotherapy-resistant Salivary Gland Cancer (2012)
  • Author(s): Shirakata T, Oka Y, Nishida S, et al
  • Journal Title: Anticancer Res Volume: 32 Pages: 1081-1085
  • Peer Reviewed
• [Journal Article] Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response (2011)
  • Author(s): Takahara A., Koido S., Nishida S., et al
  • Journal Title: Cancer Immunol Immunother Volume: 60 Pages: 1289-1297
  • Peer Reviewed
• [Journal Article] WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML Patient (2010)
  • Author(s): Oji Y, Oka Y, Nishida S, et al
  • Journal Title: Eur J Hematology Volume: 85 Pages: 358-360
  • Peer Reviewed
• [Presentation] WT1ペプチドを用いたがんの免疫療法多施設共同研究 (2011)
  • Author(s): 西田純幸
  • Organizer: 日本バイオセラピー学会
  • Place of Presentation: ダイワロイヤルネットホテル和歌山(和歌山県)
  • Year and Date: 2011-11-30
• [Presentation] WT1ペプチドを用いたがんの免疫療法多施設共同研究 (2011)
  • Author(s): 西田純幸
  • Organizer: 第24回日本バイオセラピー学会
  • Place of Presentation: ダイワロイヤルネットホテル和歌山(招待講演)
  • Year and Date: 2011-11-30
• [Presentation] Memory WT1-CTLs is a useful marker to predict the clinical outcome ; WT1 vaccine in the combination with gemcitabine (2011)
  • Author(s): Nishida S
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-04
• [Presentation] Memory WT1-CTLs is a useful marker to predict the clinical outcome ; WT1 vaccine in the combination with gemcitabine (2011)
  • Author(s): Nishida S
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] Cancer immunotherapy combined with chemotherapy for pancreatic cancer ; a phase 1 clinical trial of the combination therapy with gemcitabine and WT1-peptide-based cancer vaccine (2011)
  • Author(s): S. Nishida
  • Organizer: 日本臨床腫瘍学会
  • Place of Presentation: 横浜パシフィコ(神奈川県)
  • Year and Date: 2011-07-22
• [Presentation] Cancer immunotherapy combined with chemotherapy for pancreatic cancer ; a phase 1 clinical trial of the combination therapy with gemcitabine and WT1-peptide-based cancer vaccine (2011)
  • Author(s): Nishida S
  • Organizer: 第9回日本臨床腫瘍学会
  • Place of Presentation: 横浜パシフィコ(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] WT1 PEPTIDE-BASED CANCER VACCINE IN COMBINATION WITH GEMCITABINE IN PATIENTS WITH ADVANCED PANCREATIC CANCER-PHASE 1 CLINICAL TRIAL (2011)
  • Author(s): S. Nishida
  • Organizer: 5^<th> International conference on WT1 in Human Neoplasia
  • Place of Presentation: Italy Turin
  • Year and Date: 2011-04-15
• [Presentation] WT1 PEPTIDE-BASED CANCER VACCINE IN COMBINATION WITH GEMCITABINE IN PATIENTS WITH ADVANCED PANCREATIC CANCER-PHASE 1 CLINICAL TRIAL- (2011)
  • Author(s): Nishida S
  • Organizer: The 5^<th> International Conference on WT1 In Human Neoplasia
  • Place of Presentation: イタリア・トリノ(招待講演)
  • Year and Date: 2011-04-15
• [Presentation] A Phase I study of WT1 peptide-based cancer vaccine combined with Gemcitabine for Advanced Pancreatic Cancer (2010)
  • Author(s): S. Nishida
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] A Phase I study of WT1 peptide-based cancer vaccine combined with Gemcitabine for Advanced Pancreatic Cancer (2010)
  • Author(s): 西田純幸
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-22
• [Presentation] Phase I clinical trial of WT1 peptide-based cancer vaccine in combination with gemcitabine in patients with advanced pancreatic cancer (2010)
  • Author(s): S. Nishida
  • Organizer: Asia Clinical Oncology Society
  • Place of Presentation: 岐阜グランドホテル(岐阜県)
  • Year and Date: 2010-08-26
• [Presentation] Phase I clinical trial of WT1 peptide-based cancer vaccine in combination with gemcitabine in patients with advanced pancreatic cancer (2010)
  • Author(s): 西田純幸
  • Organizer: 9^<th> Asia Clinical Oncology Society
  • Place of Presentation: 岐阜市(招待講演)
  • Year and Date: 2010-08-25
• [Presentation] WT1ペプチドワクチン療法の癌に対する集学的治療への仲間入りを目指した臨床研究 (2010)
  • Author(s): 西田純幸
  • Organizer: 日本がん免疫学会
  • Place of Presentation: KKRホテル熊本(熊本県)
  • Year and Date: 2010-07-23
• [Presentation] WT1ペプチドワクチン療法の癌に対する集学的治療への仲間入りを目指した臨床研究 (2010)
  • Author(s): 西田純幸
  • Organizer: 第14回日本がん免疫学会
  • Place of Presentation: 熊本市
  • Year and Date: 2010-07-22
• [Presentation] WT1ペプチドワクチンと塩酸ゲムシタビンを併用した進行膵臓癌に対する新たな治療戦略 (2009)
  • Author(s): 西田純幸
  • Organizer: 日本癌免疫学会
  • Place of Presentation: 北九州国際会議場(福岡県)
  • Year and Date: 2009-06-24
• [Presentation] 進行膵臓癌に対するゲムシタビン併用WT1ペプチドワクチン療法 (2009)
  • Author(s): 西田純幸
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜パシフィコ(神奈川県)