Basic researches for developing new liver regeneration therapy using cultured autologous bone marrow derived cells in decompensated liver cirrhosis patients with hepatocellular carcinomas.
| Project/Area Number |
21790667
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAKAMI Taro Yamaguchi University, 医学部附属病院, 助教 (60511251)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨髄細胞 / 肝発癌 / 肝硬変症 |
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| Research Abstract |
Objectives : To evaluate the effects of autologous bone marrow cell infusion (ABMi) on the mechanisms of hepatocarcinogenesis, we performed frequent BMi in hepatocarcinogenic mice with liver cirrhosis. Methods : A mouse model of hepatocarcinogenesis with liver cirrhosis (DEN/GFP-CCl_4 model) was developed. In the BMi group, GFP-positive bone marrow cells from syngeneic mice were infused via the tail vein in DEN/GFP-CCl_4 model mice. Kinetics of hepatocarcinogenesis were histologically evaluated. Results : In the BMi group, foci and tumor showed significantly lower incidence and smaller number, while size was almost equal. Moreover, hepatic 8-OHdG levels were significantly lower. Conclusions : These results suggested that frequent ABMi might contribute the suppressed tumor-initiation and no tumor-promotion during stages of hepatocarcinogenesis.
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Report
(3 results)
Research Products
(41 results)
