The effect of human neutrophil peptides on intestinal inflammation as determined by proteomics approaches
| Project/Area Number |
21790672
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KANMURA Shuji Kagoshima University, 医学部・歯学部附属病院, 医員 (60448561)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | ディフェンシン / 炎症性腸疾患 / 腸管免疫 / 抗菌ペプチド / プロテオミクス / 潰瘍性大腸炎 / サイトカイン / 好中球 / プロイオミクス |
|---|
| Research Abstract |
Human neutrophil peptides (HNPs) 1-3 promoted proliferation of epithelial cell lines at low peptide concentrations ; however, higher peptide concentrations inhibited cellular proliferation. And, treatment with HNPs resulted in the increase expression of interleukin-1 (IL-8), vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) from epithelial cell lines. Additionally, after administration of HNPs to DSS-induced mouse IBD model, high histological colitis score, weight loss, and shortening of the large intestine were observed as compared to non-treated mice. These results suggest that HNPs increase the expression of proinflammatory cytokines in intestinal epithelial cells and exacerbates experimental colitis.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] The complement component C3a fragment is a potential biomarker for hepatitis C virus-related hepatocellular carcinoma.J Gastroenterol.2010
Author(s)
Kanmura S, Uto H, Sato Y, Kumagai K, Sasaki F, Moriuchi A, Oketani M, Ido A, Nagata K, Hayashi K, Stuver SO, Tsubouchi H.
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Journal Title
J Gastroenterol. 45
Pages: 459-467
Related Report
Peer Reviewed
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[Journal Article] The complement component C3a fragment is a potential biomarker for hepatitis C virus-related hepatocellular carcinoma2010
Author(s)
Shuji Kanmura, Hirofumi Uto, Yuko Sato, Koutarou Kumagai, Fumisato Sasaki, Akihiro Moriuchi, Makoto Oketani, Akio Ido, Kenji Nagata, Katsuhiro Hayashi, Serri O Stuver, Hirohito Tsubouchi
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Journal Title
Journal of gastroenterology.
Volume: 45
Pages: 459-467
NAID
Related Report
Peer Reviewed
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[Journal Article] Human Neutrophil Peptides 1-3 are useful biomarkers in patients with ulcerative colitis.2009
Author(s)
Kanmura S, Uto H, Numata M, Hashimoto S, Moriuchi A, Fujita H, Oketani M, Ido A, Kodama M, Ohi H, Tsubouchi H.
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Journal Title
Inflamm Bowel Dis. 15
Pages: 909-917
Related Report
Peer Reviewed
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