Development of liver cancer preventive methods using VA-Lip-siRNA

• Project/Area Number: 21790674
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: MURASE Kazuyuki Sapporo Medical University, 医学部, 助教 (90444918)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 移植・再生医療 / 核酸 / 癌 / 再生医学 / 脂質

Research Abstract

In this study, we established liver fibrosis model using CDAA diet model and investigated the mechanism of liver carcinogenesis induced by fibrosis. Furthermore, we examined whether the resolution of collagen deposition by siRNA-HSP47 could prevent hepatic carcinoma using CDAA diet model. Finally, we could obtain the fundamental data regarding the plausible mechanisms of liver carcinogenesis by fibrosis which should be promising for prevention of liver fibrosis.

Research Products

• [Journal Article] Two cases of myelodysplastic syndrome associated with pyoderma gangrenosum. (2011)
  • Author(s): Murase K, Sato T, Takimoto R, Kobune M, Kato J.
  • Journal Title: Rinsho zasshi Naika. In press.
  • Peer Reviewed
• [Journal Article] Tuberculous pleuritis with onset of refractory pleural effusion after chemoradiotherapy for esophageal cancer. (2011)
  • Author(s): Hirakawa M, Sato Y, Ohnuma H, Sagawa T, Ishiwatari H, Murase K, Iyama S, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi 108(2) Pages: 231-237
  • NAID: 10029388119
  • Peer Reviewed
• [Journal Article] Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital. (2010)
  • Author(s): Murase K, Iyama S, Sato T, Takimoto R, Kobune M, Kato J.
  • Journal Title: Gan To Kagaku Ryoho 37(10) Pages: 2011-2013
  • Peer Reviewed
• [Journal Article] Endoscopic findings of enteropathy-type T-cell lymphoma by double-balloon enteroscopy and capsule endoscopy. (2010)
  • Author(s): Sato Y, Ono M, Sagawa T, Takimoto R, Hirakawa M, Ohnuma H, Sato T, Iyama S, Murase K, Miyanishi K, Kobune M, Kato J.
  • Journal Title: Dig Endosc 22(3) Pages: 243-245
  • NAID: 10028187103
  • Peer Reviewed
• [Journal Article] Evaluation of the efficacy of liposomal amphotericin B. (2010)
  • Author(s): Iyama S, Murase K, Sato T, Kikuchi S, Sato Y, Kobune M, Takimoto R, Kato J.
  • Journal Title: Kansenshogaku Zasshi 84(2) Pages: 182-186
  • NAID: 10026893557
  • Peer Reviewed
• [Journal Article] Therapeutic results in patients with biphenotypic acute leukemia at Sapporo Medical University Hospital. (2010)
  • Author(s): Murase K, Kato J.
  • Journal Title: Gan To Kagaku Ryoho Volume: 37 Pages: 2011-3
  • Peer Reviewed
• [Journal Article] Endoscopic findings of enteropathy-type T-cell lymphoma by double-balloon enteroscopy and capsule endoscopy. (2010)
  • Author(s): Sato Y, Murase K
  • Journal Title: Dig Endosc Volume: 22 Pages: 243-5
  • NAID: 10028187103
  • Peer Reviewed
• [Journal Article] Evaluation of the efficacy of liposomal amphotericin B. (2010)
  • Author(s): Iyama S, Murase K
  • Journal Title: Kansenshogaku Zasshi Volume: 84 Pages: 182-6
  • NAID: 10026893557
  • Peer Reviewed
• [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34^+ leukemic cells. (2009)
  • Author(s): Kobune M, Takimoto R, Murase K, Iyama S, Sato T, Kikuchi S, Kawano Y, Miyanishi K, Sato Y, Niitsu Y, Kato J.
  • Journal Title: Cancer Sci 100(5) Pages: 948-955
  • NAID: 10025145994
  • Peer Reviewed
• [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells. (2009)
  • Author(s): Kobune M, Murase K, et al
  • Journal Title: Cancer science 100(5) Pages: 948-955
  • NAID: 10025145994
  • Peer Reviewed
• [Presentation] Ex vivo production of mature erythroblasts using coculture with cord blood medical human stromal cells (2010)
  • Author(s): 菊地尚平、村瀬和幸
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-24