Research Project
Grant-in-Aid for Young Scientists (B)
In order to dissect the epigenome of gastrointestinal cancer, we analyzed the chromatin signatures and gene expression in colorectal cancer (CRC) cells. We carried out high-throughput ChIP-seq analysis and compared the data with gene expression and microRNA (miRNA) expression signatures. We also examined the DNA methylation and histone modifications in primary CRC tissues. Through these analyses, we identified a number of epigenetically silenced miRNA genes in CRCs. Our study provided a large set of epigenome data in CRC cells, suggesting that the data set are useful tools to identify cancer related genes or miRNAs.
All 2011 2010 2009
All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (12 results) Book (3 results)
Digestion 83
Pages: 241-249
Mod Pathol
Clin Cancer Res 16
Pages: 5114-5123
130004927691
Carcinogenesis 31
Pages: 2066-2073
Cancer Sci 101
Pages: 1708-1716
10026594987
Oncogene 29
Pages: 3723-3731
PLoS Genet 6
Pages: 342-349
Breast Cancer Res Treat 122
Pages: 699-710
Oncol Rep 23
Pages: 25-33
Carcinogenesis
Volume: 31 Pages: 2066-2073
Clinical Cancer Research
Volume: 16 Pages: 5114-5123
PLoS Genetics
Volume: 6
Cancer Res 69
Pages: 9073-9082
Clin Cancer Res 15
Pages: 4356-4364
BMC Cancer 9
Pages: 198-198
Gastroenterology 137
Pages: 902-913
Pages: 3725-3732
Oncogene 28
Pages: 2643-2653
Cancer Lett 281
Pages: 24-31
Cancer Research 69