Effects of sex hormones on the pathogenesis of nonalcoholic steatohepatitis (NASH)
| Project/Area Number |
21790678
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
TAKAHASHI Atsushi Fukushima Medical University, 医学部, 助教 (40404868)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | NASH / 性差 / エストロゲン / エストロゲンレセプター |
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| Research Abstract |
The expression of messenger RNA for G-protein-coupled receptor 30 (GPR30) was significantly increased in peripheral blood mononuclear cells (PBMC) from patients with NAFLD compared with PBMC from healthy controls. Other, there was a positive correlation between estrogen receptor (ER) α and the levels of leptin. Moreover, positive correlation was observed between ER α and body mass index. On the other hand, ovariectomized mice were predisposed to liver steatosis, insulin resistance and elevation of ALT by high-fat diet. These results indicated that estrogen receptor expression and lack of estrogen might contribute to the pathogenesis of NASH.
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Report
(3 results)
Research Products
(3 results)
