Analysis of adiponectin and drugs improving insulin resistance in colorectal carcinogenesis

• Project/Area Number: 21790679
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: TAKAHASHI Hirokazu Yokohama City University, 附属病院, 助教 (70438159)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 大腸癌 / アディポネクチン / ACF / PPARγ / metformin / 大腸がん

Research Abstract

Obesity and its associated visceral fat accumulation have been reported to be linked to an elevated risk of cardiovascular disease, diabetes mellitus, and mortality, and these complications are rapidly becoming significant problems. Visceral adipose tissue is not only fat storage tissue, but also a metabolically active organ secreting many adipocytokines, such as adiponectin. Obesity is reportedly an important risk factor for CRC. Adiponectin and drugs improving insulin resistance for inhibiting colorectal carcinogenesis in mouse model and humans provides preliminary evidence, suggesting its promise for the chemoprevention of colorectal cancer. Further studies should be conducted to clarify the role that visceral fat accumulation and reduced plasma adiponectin play in obesity-related CRC prevention.

Research Products

• [Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. (2011)
  • Author(s): Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
  • Journal Title: Gut. [Epub ahead of print]
• [Journal Article] Leptin receptor is involved in STAT3 activation in human colorectal adenoma. (2010)
  • Author(s): Uchiyama T, Takahashi H, Sugiyama M, Sakai E, Endo H, Hosono K, Yoneda K, Yoneda M, Inamori M, Nagashima Y, Inayama Y, Wada K, Nakajima A.
  • Journal Title: Cancer Sci.
  • NAID: 10029290045
• [Journal Article] PPARgamma Ligand as a Promising Candidate for Colorectal Cancer Chemoprevention : A Pilot Study. (2010)
  • Author(s): Takahashi H, Hosono K, Uchiyama T, Sugiyama M, Sakai E, Endo H, Maeda S, Schaefer KL, Nakagama H, Nakajima A.
  • Journal Title: PPAR Res. 2010.Pii
• [Journal Article] Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial. (2010)
  • Author(s): Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, Koide T, Tokoro C, Abe Y, Inamori M, Nakagama H, Nakajima A.
  • Journal Title: Cancer Prev Res. 3 Pages: 1077-1083
• [Journal Article] Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. (2010)
  • Author(s): Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K, Nakagama H, Nakajima A.
  • Journal Title: Mol Carcinog. 49 Pages: 662-671
• [Journal Article] Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. (2010)
  • Author(s): Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K, Nakagama H, Nakajima A
  • Journal Title: Carcinogenesis Volume: 49 Pages: 662-671
  • Peer Reviewed
• [Journal Article] Molecular mechanisms linking adiponectin receptor signalling and cancer. (2010)
  • Author(s): Nakajima A, Endo H, Yoneda K, Fujisawa T, Sugiyama M, Hosono K, Nozaki Y, Takahashi H, Fujita K, Yoneda M, Inamori M, Shimamura T, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Wada K, Nakagama H
  • Journal Title: The Open Obesity Journal Volume: 2 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. (2010)
  • Author(s): Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, Koide T, Tokoro C, Abe Y, Inamori M, Nakagama H, Nakajima A
  • Journal Title: Cancer Prev Res Volume: 3 Pages: 1077-1083
  • Peer Reviewed
• [Journal Article] PPARgamma ligand as a promising candidate for colorectal cancer chemoprevention : A pilot study. (2010)
  • Author(s): Takahashi H, Hosono K, Uchiyama T, Sugiyama M, Sakai E, Endo H, Maeda S, Schaefer KL, Nakagama H, Nakajima A
  • Journal Title: PPAR Res Volume: 2010
  • Peer Reviewed
• [Journal Article] Leptin receptor is involved in STAT3 activation in human colorectal adenoma. (2010)
  • Author(s): Uchiyama T, Takahashi H, Sugiyama M, Sakai E, Endo H, Hosono K, Yoneda K, Yoneda M, Inamori M, Nagashima Y, Inayama Y, Wada K, Nakajima A
  • Journal Title: Cancer Sci. Volume: 102 Pages: 367-372
  • NAID: 10029290045
  • Peer Reviewed
• [Journal Article] Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition. (2009)
  • Author(s): Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Gut. 58 Pages: 1637-1643
• [Journal Article] Identification of Cystatin SN as a novel tumor marker for colorectal cancer. (2009)
  • Author(s): Yoneda K, Iida H, Endo H, Hosono K, Akiyama T, Takahashi H, Inamori M, Abe Y, Yoneda M, Fujita K, Kato S, Nozaki Y, Ichikawa Y, Uozaki H, Fukayama M, Shimamura T, Kodama T, Aburatani H, Miyazawa C, Ishii K, Hosomi N, Sagara M, Takahashi M, Ike H, Saito H, Kusakabe A, Nakajima A.
  • Journal Title: Int J Oncol. 35 Pages: 33-40
• [Journal Article] Correlation of the plasma level of insulin-like growth factor-1 with the number of aberrant crypt foci in male individuals. (2009)
  • Author(s): Takahashi H, Takayama T, Hosono K, Yoneda K, Endo H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakagama H, Nakajima A.
  • Journal Title: Mol Med Report. 2 Pages: 339-343
• [Journal Article] Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. (2009)
  • Author(s): Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Int J Oncol. 34 Pages: 339-344
• [Journal Article] Involvement of JNK Pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions (2009)
  • Author(s): Endo H, Hosono K, Fujisaw T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Gut 58 Pages: 1637-1643
  • Peer Reviewed
• [Journal Article] Identification of Cystatin SN as a novel tumor marker for colorectal cancer (2009)
  • Author(s): Yoneda K, Iida H, Endo H, Hosomo K, Akiyama T, Yoneda M, Fujita K, Kato S, Nozaki Y, Ichikawa Y, Uozaki H, Fukayama M, Shimamura T, Kodame T, Aburatani N, Sagara M, Takahashi M, Ike H, Saito H, Kusakabe A, Nakajima A
  • Journal Title: Int J Oncol 35 Pages: 33-40
  • Peer Reviewed
• [Journal Article] Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR path way (2009)
  • Author(s): Sugiyama M, Takahashi H, Hosomo K, Endo H, Kato S, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Wada K, Nakagama H, Nakajima A
  • Journal Title: Int J Oncol 34 Pages: 339-344
  • Peer Reviewed
• [Journal Article] Correlation of the plasma level of insulin-like growth factor-1 with the number of aberrant crypt foci in male individuals. (2009)
  • Author(s): Takahashi H, Takayama T, Hosono K, Yoneda K, Endo H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakagama H, Nakajima A.
  • Journal Title: Mol Med Rep. 2 Pages: 339-343
  • Peer Reviewed
• [Journal Article] Association of visveral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clincal population. (2009)
  • Author(s): Takahashi H, Takayama T, Yoneda K, Endo H, Iida H, Sugiyama M, Fujita K, Yoneda M, Inamori M, Abe Y, Sasito S, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Cancer Sci. 100 Pages: 29-32
  • Peer Reviewed
• [Presentation] 大腸発癌におけるIL-6の作用解析 (2011)
  • Author(s): 内山崇, 高橋宏和, 酒井英嗣, 杉山美智子, 細野邦広, 遠藤宏樹, 中島淳
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ16
  • Place of Presentation: 京都
  • Year and Date: 2011-02-19
• [Presentation] 肥満と大腸癌:大腸腫瘍を増大させるレプチンシグナル (2011)
  • Author(s): 遠藤宏樹, 内山崇, 酒井英嗣, 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ16
  • Place of Presentation: 京都
  • Year and Date: 2011-02-19
• [Presentation] The effect of resveratrol on azoxymethane (AOM)-induced colon carcinogenesis in mice with aberrant crypt foci (ACF) (2010)
  • Author(s): Sakai E, Endo H, Uchiyama T, Hosono K, Sugiyama M, Takahashi H, Nakajima A
  • Organizer: 9^<th> Annual AACR International Conference Frontiers in Cancer Prevention Research poster session
  • Place of Presentation: Philadelphia
  • Year and Date: 2010-11-09
• [Presentation] Metformin treatment suppresses colorectal aberrant crypt foci in humans : Results from a short-term feasibility study (2010)
  • Author(s): Hosono K, Takahashi H, Sakai E, Uchiyama T, Endo H, Nakajima A
  • Organizer: 9^<th> Annual AACR International Conference Frontiers in Cancer Prevention Research poster session
  • Place of Presentation: Philadelphia
  • Year and Date: 2010-11-09
• [Presentation] Relationship of human aberrant crypt foci and formation of colorectal polyps (2010)
  • Author(s): Takahashi H, Sakai E, Uchiyama T, Sugiyama M, Hosono K, Endo H, Nakajima A
  • Organizer: 9^<th> Annual AACR International Conference Frontiers in Cancer Prevention Research poster session
  • Place of Presentation: Philadelphia
  • Year and Date: 2010-11-09
• [Presentation] Relationship of human aberrant crypt foci and formation of colorectal polyps. (2010)
  • Author(s): Takahashi H, Sakai E, Uchiyama T, Sugiyama M, Hosono K, Endo H, Nakajima A
  • Organizer: 9^<th> annual AACR international conference frontiers in cancer prevention research
  • Place of Presentation: Philadelphia, USA.
  • Year and Date: 2010-11-09
• [Presentation] Metformin treatment suppresses colorectal aberrant crypt foci in humans : Results from a short-term feasibility study. (2010)
  • Author(s): Hosono K, Takahashi H, Sakai E, Uchiyama T, Endo H, Nakajima A
  • Organizer: 9^<th> annual AACR international conference frontiers in cancer prevention research
  • Place of Presentation: Philadelphia, USA.
  • Year and Date: 2010-11-09
• [Presentation] The effect of resveratrol on azoxymethane (AOM)-induced colon carcinogenesis in mice with aberrant crypt foci (ACF). (2010)
  • Author(s): Sakai E, Endo H, Uchiyama T, Hosono K, Sugiyama M, Takahashi H, Nakajima A
  • Organizer: 9^<th> annual AACR international conference frontiers in cancer prevention research
  • Place of Presentation: Philadelphia, USA.
  • Year and Date: 2010-11-09
• [Presentation] Analysis of human aberrant crypt foci after colorectal polypectomy (2010)
  • Author(s): Takahashi H, Sakai E, Sugiyama M, Uchiyama T, Iida H, Hosono K, Endo H, Sakamoto Y, Koide T, Tokoro C, Inamori M, Abe Y, Maeda S, Nakajima A
  • Organizer: 2010 18^<th> UEGW poster session
  • Place of Presentation: Barcelona
  • Year and Date: 2010-10-27
• [Presentation] Analysis of human aberrant crypt foci after colorectal polypectomy. (2010)
  • Author(s): Takahashi H, Sakai E, Sugiyama M, Uchiyama T, Iida H, Hosono K, Endo H, Sakamoto Y, Koide T, Tokoro C, Inamori M, Abe Y, Maeda S, Nakajima A
  • Organizer: 18^<th> United European Gastroenterology Week
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 2010-10-27
• [Presentation] Leptin stimulate colorectal carcinogenesis through JAK/STAT signal pathway via leptin receptor (2010)
  • Author(s): Uchiyama T, Takahashi H, Sugiyama M, Sakai E, Endo H, Hosono K, Maeda S, Nakajima A
  • Organizer: 2010 18^<th> UEGW poster session
  • Place of Presentation: Barcelona
  • Year and Date: 2010-10-25
• [Presentation] 大腸発癌過程におけるTNF-α関連因子の解析 (2010)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第52回日本消化器病学会大会 パネル18大腸がん研究の新たな展開と治療戦略
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-15
• [Presentation] 大腸発癌過程におけるTNF-α関連因子の解析 (2010)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第52回日本消化器病学会大会
  • Place of Presentation: 横浜,パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] 大腸発癌におけるレジスチンおよびTNFαの相関解析 (2010)
  • Author(s): 高橋宏和, 内山崇, 中島淳
  • Organizer: 第52回日本消化器病学会大会 シンポジウム6メタボリック症候群における消化と吸収
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 大腸癌治療・予防の新しい分子標的としてのレプチンシグナル経路の解析 (2010)
  • Author(s): 内山崇, 高橋宏和, 遠藤宏樹, 細野邦広, 飯田洋, 坂本康成, 藤田浩司, 古出智子, 米田正人, 所知加子, 阿部泰伸, 稲森正彦, 桐越博之, 小林規俊, 嶌村健, 窪田賢輔, 斉藤聡, 中島淳
  • Organizer: 第52回日本消化器病学会大会
  • Place of Presentation: 横浜,パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 大腸発癌におけるレジスチンおよびTNFαの相関解析 (2010)
  • Author(s): 高橋宏和, 内山崇, 中島淳
  • Organizer: 第52回日本消化器病学会大会
  • Place of Presentation: 横浜,パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] Analysis of the TNF-alpha, TNF-R1 and TNF-R2 in colorectal adenoma (2010)
  • Author(s): Hosono K, Endo H, Sugiyama M, Takahashi H, Nakajima A
  • Organizer: Poster session Colorectal cancer (3) 2010 JCA
  • Place of Presentation: Osaka
  • Year and Date: 2010-09-23
• [Presentation] Analysis of aberrant crypt foci as an effective predictor after colorectal polypectomy (2010)
  • Author(s): Takahashi H, Sakai E, Uchiyama T, Sugiyama M, Hosono K, Endo H, Maeda S, Nakajima A
  • Organizer: English Workshops Cancer prevention and chemoprevention 2010 JCA
  • Place of Presentation: Osaka
  • Year and Date: 2010-09-23
• [Presentation] Analysis of aberrant crypt foci as an effective predictor after colorectal polypectomy. (2010)
  • Author(s): Takahashi H, Sakai E, Uchiyama T, Sugiyama M, Hosono K, Endo H, Maeda S, Nakajima A
  • Organizer: 2010 JCA
  • Place of Presentation: Osaka, Osaka International Convention Center.
  • Year and Date: 2010-09-23
• [Presentation] Analysis of the TNF-alpha, TNF-R1 and TNF-R2 in colorectal adenoma (2010)
  • Author(s): Hosono K, Endo H, Sugiyama M, Takahashi H, Nakajima A
  • Organizer: 2010 JCA
  • Place of Presentation: Osaka, Osaka International Convention Center.
  • Year and Date: 2010-09-23
• [Presentation] Leptin regulates colorectal tumor growth through Stat3 signaling (2010)
  • Author(s): Endo H, Uchiyama T, Sakai E, Sugiyama M, Hosono K, Takahashi H, Maeda S, Nakajima A
  • Organizer: Poster session Animal model for carcinogenesis (3) 2010 JCA
  • Place of Presentation: Osaka
  • Year and Date: 2010-09-22
• [Presentation] Investigation of IL-6 over ecpression in chemical induced colorectal cancer model (2010)
  • Author(s): Sugiyama M, Sakai E, Uchiyama T, Hosono K, Endo H, Takahashi H, Nakajima A
  • Organizer: Poster session Animal model for carcinogenesis (1) 2010 JCA
  • Place of Presentation: Osaka
  • Year and Date: 2010-09-22
• [Presentation] Leptin regulates colorectal tumor growth through Stat3 signaling (2010)
  • Author(s): Endo H, Uchiyama T, Sakai E, Sugiyama M, Hosono K, Takahashi H, Maeda S, Nakajima A
  • Organizer: 2010 JCA
  • Place of Presentation: Osaka, Osaka International Convention Center.
  • Year and Date: 2010-09-22
• [Presentation] Investigation of IL-6 over ecpression in chemical induced colorectal cancer model (2010)
  • Author(s): Sugiyama M, Sakai E, Uchiyama T, Hosono K, Endo H, Takahashi H, Nakajima A
  • Organizer: 2010 JCA
  • Place of Presentation: Osaka, Osaka International Convention Center.
  • Year and Date: 2010-09-22
• [Presentation] 大腸発がんにおけるレプチンシグナルの役割解明 (2010)
  • Author(s): 高橋宏和, 内山崇, 中島淳
  • Organizer: 第1回GI-Metabolism Forum
  • Place of Presentation: 京都
  • Year and Date: 2010-08-28
• [Presentation] 大腸腺腫切除後の再発予測因子としてのaberrant crypt fociの検討 (2010)
  • Author(s): 高橋宏和, 細野邦広, 中島淳
  • Organizer: 第49回日本消化器がん検診学会総会 シンポジウム
  • Place of Presentation: 沖縄
  • Year and Date: 2010-06-11
• [Presentation] Critical role of leptin in the regulation of colorectal tumor growth through Stat3 signaling : Tumor growth induced by dietary intake (2010)
  • Author(s): Endo H, Hosono K, Uchiyama T, Iida H, Fujita K, Takahashi H, Yoneda M, Inamori M, Kirikoshi H, Kubota K, Nakajima A
  • Organizer: Digestive Disease Week 2010 Poster Session
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-02
• [Presentation] Critical role of leptin in the regulation of colorectal tumor growth through STAT3 signaling : tumor growth induced by dietary intake. (2010)
  • Author(s): Endo H, Hosono K, Uchiyama T, Iida H, Fujita K, Takahashi H, Yoneda M, Inamori M, Kirikoshi H, Kubota K, Nakajima A
  • Organizer: DIGESTIVE DISEASE WEEK 2010
  • Place of Presentation: New Orleans, USA.
  • Year and Date: 2010-05-02
• [Presentation] 肥満と大腸がん (2010)
  • Author(s): 中島淳, 高橋宏和
  • Organizer: 第96回日本消化器病学会総会 トピックスセミナー
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-24
• [Presentation] 肥満と大腸がん (2010)
  • Author(s): 中島淳, 高橋宏和
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟,新潟県民会館
  • Year and Date: 2010-04-24
• [Presentation] 食事摂取により増大する大腸腫瘍:レプチンシグナルの関与 (2010)
  • Author(s): 遠藤宏樹, 高橋宏和, 中島淳
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟,新潟県民会館
  • Year and Date: 2010-04-24
• [Presentation] 食事摂取により増大する大腸腫瘍:レプチンシグナルの関与 (2010)
  • Author(s): 遠藤宏樹, 高橋宏和, 中島淳
  • Organizer: 第96回日本消化器病学会総会 シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-23
• [Presentation] 大腸腫瘍進展における糖尿病関連因子の相関解析 (2010)
  • Author(s): 高橋宏和, 細野邦広, 内山崇, 飯田洋, 遠藤宏樹, 野崎雄一, 坂本康成, 藤田浩司, 米田正人, 古出智子, 所知加子, 後藤歩, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
  • Organizer: 第96回日本消化器病学会総会 ポスター
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-22
• [Presentation] 大腸癌における生活習慣関連因子の実態と化学予防による対策の可能性 (2010)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第96回日本消化器病学会総会 パネルディスカッション
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-22
• [Presentation] 大腸腫瘍におけるレプチンシグナル経路の解析 (2010)
  • Author(s): 内山崇, 高橋宏和, 中島淳
  • Organizer: 第96回日本消化器病学会総会 パネルディスカッション
  • Place of Presentation: 新潟
  • Year and Date: 2010-04-22
• [Presentation] 大腸腫瘍進展における糖尿病関連因子の相関解析 (2010)
  • Author(s): 高橋宏和, 細野邦広, 内山崇, 飯田洋, 遠藤宏樹, 野崎雄一, 坂本康成, 藤田浩司, 米田正人, 古出智子, 所知加子, 後藤歩, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟,新潟県民会館
  • Year and Date: 2010-04-22
• [Presentation] 大腸癌における生活習慣関連因子の実態と化学予防による対策の可能性 (2010)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟,新潟県民会館
  • Year and Date: 2010-04-22
• [Presentation] 大腸腫瘍におけるレプチンシグナル経路の解析 (2010)
  • Author(s): 内山崇, 高橋宏和, 中島淳
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟,新潟県民会館
  • Year and Date: 2010-04-22
• [Presentation] Metformin Suppresses Azoxymethane-Induced Colorectal Carcinogenesis Via Activating AMP-Activated Protein Kinase (2010)
  • Author(s): Hosono K, Endo H, Nakajima A, Takahashi H
  • Organizer: 101^<st> AACR Annual Meeting 2010 poster session
  • Place of Presentation: Washington DC.
  • Year and Date: 2010-04-21
• [Presentation] Metformin suppresses azoxymethane-induced colorectal carcinogenesis via activating AMP-activated protein kinase. (2010)
  • Author(s): Hosono K, Endo H, Nakajima A, Takahashi H
  • Organizer: AACR 101st annual meeting
  • Place of Presentation: Washington D.C., USA.
  • Year and Date: 2010-04-21
• [Presentation] Leptin Signaling Regulates Colorectal Tumor Growth Through Stat3 Signaling : Tumor Growth Induced by Dietary Intake (2010)
  • Author(s): Endo H, Hosono K, Uchiyama T, Takahashi H, Inamori M, Nakajima A
  • Organizer: 101^<st> AACR Annual Meeting 2010 poster session
  • Place of Presentation: Washington DC.
  • Year and Date: 2010-04-19
• [Presentation] Leptin signaling regulates colorectal tumor growth through Stat3 signaling : tumor growth induced by dietary intake. (2010)
  • Author(s): Endo H, Hosono K, Uchiyama T, Takahashi T, Inamori M, Nakajima A
  • Organizer: AACR 101st annual meeting
  • Place of Presentation: Washington D.C., USA.
  • Year and Date: 2010-04-19
• [Presentation] 抗糖尿病薬メトホルミンを用いた生活習慣病における大腸癌の予防戦略 (2010)
  • Author(s): 細野邦広, 遠藤宏樹, 高橋宏和, 稲森正彦, 中島淳
  • Organizer: 第6回日本消化管学会総会学術集会 トピックフォーラム
  • Place of Presentation: 福岡
  • Year and Date: 2010-02-20
• [Presentation] Crucial role of leptin in the regulation of colorectal tumor growth through Stat3 signaling : Tumor growth induced by dietary intake (2010)
  • Author(s): Endo H, Hosono K, Uchiyama T, Takahashi H, Inamori M, Nakajima A
  • Organizer: 8^<th> AACR/JCA Joint Conference
  • Place of Presentation: Hawaii
  • Year and Date: 2010-02-09
• [Presentation] Crucial role of leptin in the regulation of colorectal tumor growth through Stat3 signaling : Tumor growth induced by dietary intake (2010)
  • Author(s): Endo H, Hosono K, Uchiyama T, Takahashi H, Inamori M, Nakajima A
  • Organizer: 8^<th> AACR/JCA Joint Conference
  • Place of Presentation: Waikoloa, Hawaii, USA
  • Year and Date: 2010-02-09
• [Presentation] Aberrant crypt fociとサプリメントの相関解析 (2009)
  • Author(s): 高橋宏和, 細野邦広, 中島淳
  • Organizer: 第51回日本消化器病学会大会 パネル24消化吸収機能を標的とした機能性食品の展望
  • Place of Presentation: 京都
  • Year and Date: 2009-10-17
• [Presentation] Analysis of serum leptin level and colorectal adenoma (2009)
  • Author(s): Uchiyama T, Sugiyama M, Hosono K, Endo H, Takahashi H, Nakajima A
  • Organizer: Poster session colorectal cancer (1) 2009 JCA
  • Place of Presentation: Yokohama
  • Year and Date: 2009-10-02
• [Presentation] Natural history of human aberrant crypt foci (2009)
  • Author(s): Takahashi H, Hosono K, Sugiyama M, Endo H, Nakajima A
  • Organizer: Poster session colorectal cancer (2) 2009 JCA
  • Place of Presentation: Yokohama
  • Year and Date: 2009-10-02
• [Presentation] Natural history of human aberrant crypt foci (2009)
  • Author(s): Takahashi H, Hosono K, Sugiyama M, Endo H, Nakajima A
  • Organizer: 2009 JCA, Poster Session
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Metformin suppresses the colorectal carcinogenesis via activationg AMP kinase (2009)
  • Author(s): Hosono K, Endo H, Sugiyama M, Takahashi H, Nakajima A
  • Organizer: Oral session Cancer preven/Chemoprevention 2009 JCA
  • Place of Presentation: Yokohama
  • Year and Date: 2009-10-01
• [Presentation] メトホルミンによるAMPKの活性化と大腸発癌抑制についての検討 (2009)
  • Author(s): 細野邦宏、遠藤宏樹、杉山美智子、高橋宏和、中島淳
  • Organizer: 第65回 日本癌学会学術総会 一般演題
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] シンポジウム2「消化器がんの危険因子とその対策・予後」生活習慣における大腸がんの危険因子と治療戦略 (2009)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第48回日本消化器がん検診学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-19
• [Presentation] 消化器がんの危険因子とその対策・予後生活習慣における大腸がんの危険因子と治療戦略 (2009)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第48回日本消化器がん検診学会総会 シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-19
• [Presentation] Plasma IGF-1 Is Correlated with Dysplastic Aberrant Crypt Foci in Men. (2009)
  • Author(s): Takahashi H, Hosono K, Endo H, Yoneda K, Akiyama T, Inamori M, Abe Y, Kato S, Uchiyama T, Iida H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Organizer: Digestive Disease Week 2009 AGA Institute Poster Session
  • Place of Presentation: Chicago
  • Year and Date: 2009-06-03
• [Presentation] Plasma IGF-1 Is Correlated with Dysplastic Aberrant Crypt Foci in Men. (2009)
  • Author(s): Takahashi H, Hosono K, Endo H, Yoneda K, Akiyama T, Inamori M, Abe Y, Kato S, Uchiyama T, Iida H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Kobayashi M, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Organizer: Digestive Disease Week 2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-06-03
• [Presentation] 大腸その他3 Aberrant crypt fociの自然史に対する解析 (2009)
  • Author(s): 高橋宏和, 細野邦広, 遠藤宏樹, 米田恭子, 加藤真吾, 内山崇, 飯田洋, 馬渡弘典, 野崎雄一, 秋山智之, 藤田浩司, 米田正人, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
  • Organizer: 第77回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋(一般口演)
  • Year and Date: 2009-05-21
• [Presentation] Aberrant crypt fociの自然史に対する解析 (2009)
  • Author(s): 高橋宏和, 細野邦広, 遠藤宏樹, 米田恭子, 加藤真吾, 内山崇, 飯田洋, 馬渡弘典, 野崎雄一, 秋山智之, 藤田浩司, 米田正人, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
  • Organizer: 第77回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-05-21
• [Presentation] ワークショップ3 大腸癌の予防AMPKをターゲットとする新たな大腸化学発癌予防 (2009)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] 大腸癌の予防AMPKをターゲットとする新たな大腸化学発癌予防 (2009)
  • Author(s): 細野邦広, 高橋宏和, 中島淳
  • Organizer: 第95回日本消化器病学総会ワーククショップ
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] 内蔵脂肪およびアディポサイトカインの大腸発癌に関する解析 (2009)
  • Author(s): 高橋宏和, 細野邦広, 中島淳, 米田恭子, 遠藤宏樹, 加藤真吾, 内山崇, 飯田洋, 馬渡弘典, 野崎雄一, 秋山智之, 藤田浩司, 米田正人, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] JNK plays a crucial role in promotion of the early stage of colon carcinogenesis under the high-fat diet condition (2009)
  • Author(s): Endo H, Hosono K, Yoneda, K, Takahashi H, Nakajima A
  • Organizer: AACR 100^<th> Annual Meeting 2009
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2009-04-20
• [Presentation] JNK plays a crucial role in promotion of the early stage of colon carcinogenesis under the high-fat condition (2009)
  • Author(s): Endo H, Hosono K, Yoneda K, Takahashi H, Nakajima A.
  • Organizer: 100^<th> AACR Annual Meeting 2009
  • Place of Presentation: Denver
  • Year and Date: 2009-04-19
• [Presentation] Natural history of human aberrant crypt foci after colorectal polypectomy (2009)
  • Author(s): Takahashi H, Hosono K, Endo H, Yoneda K, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Organizer: 100^<th> AACR Annual Meeting 2009
  • Place of Presentation: Denver
  • Year and Date: 2009-04-19
• [Presentation] Natural history of human aberrant crypt foci after colorectal polypectomy (2009)
  • Author(s): Takahashi H, Hosono K, Endo H, Yoneda K, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Organizer: AACR 100^<th> Annual Meeting 2009
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2009-04-19
• [Book] 大腸発癌におけるレプチンシグナルの役割解明 The GI Forefront 6巻2号 (2011)
  • Author(s): 高橋宏和, 内山崇, 中島淳
• [Book] アディポサイトカインと大腸癌 臨床消化器内科 26巻2号 (2011)
  • Author(s): 遠藤宏樹, 細野邦広, 酒井英嗣, 内山崇, 高橋宏和, 中島淳
• [Book] 肥満と大腸癌 肥満と消化器疾患 (2010)
  • Author(s): 高橋宏和, 遠藤宏樹, 中島淳
• [Book] 【メタボリックシンドロームと消化器疾患】 メタボリックシンドロームと大腸癌 G.I.Research 18巻3号 (2010)
  • Author(s): 内山崇, 高橋宏和, 中島淳
• [Book] 【性差からみた消化器疾患の病態と予後】 内臓脂肪およびアディポネクチンと大腸発癌の性差 消化器内科 50巻4号 (2010)
  • Author(s): 高橋宏和, 内山崇, 中島淳
• [Book] Aberrant crypt fociとサプリメントの相関解析 消化と吸収 32巻1号 (2010)
  • Author(s): 高橋宏和, 細野邦広, 中島淳
• [Book] 大腸腫瘍のサロゲートマーカーとしてのaberrant crypt foci-自然史および化学発癌予防への臨床応用 臨床消化器内科 25巻1号 (2010)
  • Author(s): 高橋宏和, 細野邦広, 中島淳
  • Total Pages: 135
• [Book] 内臓脂肪およびアディポネクチンと大腸発癌の性差 (2010)
  • Author(s): 高橋宏和, 内山崇, 中島淳
  • Total Pages: 5
  • Publisher: 科学評論社
• [Book] Aberrant crypt fociとサプリメントの相関解析 (2010)
  • Author(s): 高橋宏和, 細野邦広, 中島淳
  • Total Pages: 4
  • Publisher: 日本消化吸収学会
• [Book] 肥満と大腸癌 (2010)
  • Author(s): 高橋宏和, 遠藤宏樹, 中島淳
  • Total Pages: 15
  • Publisher: 日本消化器病学会
• [Book] 大腸発癌における生活習慣因子の相関および化学発癌予防への臨床応用(総説) 横浜医学 60巻4号 (2009)
  • Author(s): 高橋宏和
• [Book] 中島淳高脂肪食制限による大腸発癌抑制の分子機序 消化器科 49巻5号 (2009)
  • Author(s): 遠藤宏樹, 細野邦広, 高橋宏和
• [Book] 【メタボリックシンドローム】 メタボリックシンドロームと大腸癌 BIO Clinica 24巻4号 (2009)
  • Author(s): 内山崇, 細野邦弘, 遠藤宏樹, 高橋宏和, 中島淳
• [Book] 高脂肪食制限による大腸発癌抑制の分子機序 (2009)
  • Author(s): 遠藤宏樹, 細野邦広, 高橋宏和, 中島淳
  • Total Pages: 6
  • Publisher: 科学評論社
• [Book] 大腸腫瘍のサロゲートマーカーとしてのaberrant crypt foci自然史および化学発癌予防への臨床応用 (2009)
  • Author(s): 高橋宏和, 細野邦広, 中島淳
  • Total Pages: 3
  • Publisher: 日本メディカルセンター