Immunological Study of Autoimmune Extrapancreatic Exocrinopathy In Autoimmune Pancreatitis Animal Model

• Project/Area Number: 21790689
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kansai Medical University
• Principal Investigator: SAKAGUCHI Yutaku 関西医科大学, 学医学部, 助教 (60340692)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 自己免疫性膵炎 / 制御性T 細胞 / 全身性硬化病変 / Th-17 / WBN/Kob / 制御性T細胞 / Th1/2 / IL-10 / Th1 / 2 / WBN / Kob

Research Abstract

The activation of Th1/Th2 and regulatory T cell, producted IL-4, IL-10 that promoting the class switch to IgG2b. It suggested the involvement with the morbidity and aggravation in WBN/Kob rats.

Research Products

• [Journal Article] Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin (2012)
  • Author(s): Nakajima A, Fukui T
  • Journal Title: J Gastroenterol Volume: 47(9) Pages: 978-87
  • Peer Reviewed
• [Journal Article] The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration (2012)
  • Author(s): Fukui Y, Uchida K, Sumimoto K, Kusuda T, Miyoshi H, Koyabu M, Ikeura T, Sakaguchi Y, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Shikata N, Sakaida N, Uemura Y, Satoi S, Kwon AH, Okazaki K
  • Journal Title: J Gastroenterol
  • NAID: 10031184065
  • Peer Reviewed
• [Journal Article] Dilatation of the Bile and Pancreatic Ducts due to Compression by an Unruptured Abdominal Aortic Aneurysm (AAA) : A Case Ameliorated by an Endovascular Stent Grafting (2012)
  • Author(s): T, Suzuki R, Sakaguchi Y, Shibatani N, Hachimine D, Uchida K, Nishio A, Seki T, Okazaki K
  • Journal Title: Intern Med Volume: 51(19) Pages: 2749-52
  • NAID: 130002062047
  • Peer Reviewed
• [Journal Article] Regulatory T cells in type 1 autoimmune pancreatitis (2012)
  • Author(s): Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukata N, Sumimoto K, Fukui Y, Sakaguchi Y, Ikeura T, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Okazaki K
  • Journal Title: Int J Rheumatol Volume: 2012 Pages: 795026-795026
  • Peer Reviewed
• [Journal Article] Regulatory T cells in Type 1 autoimmune pancreatitis (2012)
  • Author(s): Uchida K
  • Journal Title: International journal of rheumatology Volume: 795,026 Pages: 726-32
  • DOI: 10.1155/2012/795026
  • Peer Reviewed
• [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis (2011)
  • Author(s): Fukui T, Kishimoto M, Nakajima A,Yamashina M, Nakayama S, Kusuda T, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K.
  • Journal Title: J Gastroenterol Volume: 46(4) Pages: 456-68
  • NAID: 10029028438
  • Peer Reviewed
• [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis (2011)
  • Author(s): Toshiro Fukui
  • Journal Title: Journal of Gastroenterology Volume: 46 Issue: 4 Pages: 456-168
  • DOI: 10.1007/s00535-010-0364-8
  • Peer Reviewed
• [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis. (2011)
  • Author(s): Fukui T
  • Journal Title: Journal of gastroenterology Volume: 46(4) Pages: 456-468
  • Peer Reviewed
• [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases (2010)
  • Author(s): Koyabu M, Uchida K, Miyoshi H, Sakaguchi Y, Fukui T, Ikeda H, Takaoka M, Hirohara J, Nishio A, Uemura Y, Uemoto S, Okazaki K
  • Journal Title: J Gastroenterol Volume: 45(7) Pages: 732-41
  • Peer Reviewed
• [Journal Article] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells. J Gastroenterol (2010)
  • Author(s): Koyabu M, Uchida K, Fukata N, Kusuda T, Ikeura T, Sakaguchi Y, Yoshida K, Shimatani M, Fukui T, Matsushita M, Uemura Y, Kaibori M, Takaoka M,Nishio A, Okazaki K
  • Journal Title: J Gastroenterol Volume: 45(1) Pages: 122-9
  • Peer Reviewed
• [Journal Article] Idiopathic duct-centric pancreatitis (IDCP) with immunological studies (2010)
  • Author(s): Kusuda T, Uchida K, Satoi S, Koyabu M, Fukata N, Miyoshi H, Ikeura T, Sakaguchi Y, Yoshida K, Fukui T, Shimatani M, Matsushita M, Takaoka M, Nishio A, Uemura Y, Kwon AH, Okazaki K
  • Journal Title: Intern Med Volume: 49(23) Pages: 2569-75
  • NAID: 130000413401
  • Peer Reviewed
• [Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases. (2010)
  • Author(s): Koyabu M
  • Journal Title: Journal of gastroenterology Volume: 45(7) Pages: 732-741
  • Peer Reviewed
• [Journal Article] Idiopathic Duct-Centric Pancreatitis (IDCP) with Immunological Studies. (2010)
  • Author(s): Kusuda T
  • Journal Title: Internal medicine Volume: 49(23) Pages: 2569-2575
  • Peer Reviewed
• [Journal Article] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells (2010)
  • Author(s): Koyabu M
  • Journal Title: Journal of gastroenterology 39(2) Pages: 122-129
  • Peer Reviewed
• [Journal Article] Long-term outcome of autoimmune pancreatitis (2009)
  • Author(s): Uchida K, Yazumi S, Nishio A, Kusuda T, Koyabu M, Fukata M, Miyoshi H, Sakaguchi Y, Fukui T, Matsushita M, Takaoka M, Okazaki K
  • Journal Title: J Gastroenterol Volume: 44(7) Pages: 726-32
  • NAID: 10025176191
  • Peer Reviewed
• [Journal Article] Long-term outcome of autoimmune pancreatitis (2009)
  • Author(s): Uchida K
  • Journal Title: Journal of gastroenterology 44(7) Pages: 726-32
  • Peer Reviewed
• [Presentation] le role of ICOS and IL-10 Positive Regulatory T Cells in the Development of IgG4-related Autoimmune Pancre (2011)
  • Author(s): Uchida K
  • Organizer: American Pancreatic Association Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-11-01
• [Presentation] Analysis of ICOS and IL-10 positive regulatory T cells in patients with autoimmune pancreatitis. (2010)
  • Author(s): K Uchida
  • Organizer: American Pancreatic Association Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-11-04
• [Presentation] AN ANIMAL MODEL FOR ACUTE,CHRONIC,AND SEVERE PANCREATITIS WITH THE ANALYSES OF REGENERATION MECHANISMS (2009)
  • Author(s): Y Sakaguchi,T Kusuda,M Koyabu,M Fukata,H Miyoshi,T Fukui,K Uchida,M Matsushita,M Takaoka,A Nishio, K Okazaki
  • Organizer: 40th Anniversary Joint Meeting of the American Pancreatic Association & Japan Pancreas Society
  • Place of Presentation: Honolulu,USA
  • Year and Date: 2009-11-07
• [Presentation] AN ANIMAL MODEL FOR ACUTE, CHRONIC, AND SEVERE PANCREATITIS WITH THE ANALYSES OF REGENERATION MECHANISMS (2009)
  • Author(s): 坂口雄沢
  • Organizer: 40th Anniversary Joint Meeting of the American Pancreatic Association & Japan Pancreas Society
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2009-11-07
• [Presentation] WBN/Kob ラットの慢性膵炎・膵外病変における自己免疫性機序の関与及び制御性T 細胞の免疫応答 (2009)
  • Author(s): 坂口雄沢、深田憲将、三好秀明、楠田武生、福井寿朗、内田一茂、西尾彰功、岡崎和一
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 北海道京王プラザホテル札幌
  • Year and Date: 2009-05-08
• [Presentation] WBN/Kobラットの慢性膵炎・膵外病変における自己免疫性機序の関与及び制御性T細胞の免疫応答 (2009)
  • Author(s): 坂口雄沢
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌 北海道厚生年金会館ウェルシティ札幌
  • Year and Date: 2009-05-07
• [Book] 新版 自己免疫性膵炎 (2009)
  • Author(s): 内田一茂, 坂口雄沢, 岡崎和一
  • Total Pages: 240
  • Publisher: 診断と治療社