Exploration of novel therapeutic targets of human pancreatic cancers by miRNA expressing vectors and DNA microarrays
| Project/Area Number |
21790694
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The University of Tokyo (2010)
National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East (2009) |
|---|
Principal Investigator |
IZUMIYA Masashi The University of Tokyo, 医学部附属病院, 特任臨床医 (90532739)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | 胆道学 / 膵臓学 / マイクロRNA / マイクロアレイ / スクリーニング / 膵がん |
|---|
| Research Abstract |
To explore new therapeutic targets of pancreatic cancer, which is a representative hard-to-cure solid caner, we developed a functional screening assay using microRNA expressing virus library and custom-made microarrays. Using this functional screening assay, we explored microRNAs that control proliferation of pancreatic cancer cells and identified five microRNA that remarkably repress cell proliferation. These microRNAs and their targets appear to be promising novel therapeutic targets of pancreatic cancers.
|
Report
(3 results)
Research Products
(12 results)
