| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
To explore new therapeutic targets of pancreatic cancer, which is a representative hard-to-cure solid caner, we developed a functional screening assay using microRNA expressing virus library and custom-made microarrays. Using this functional screening assay, we explored microRNAs that control proliferation of pancreatic cancer cells and identified five microRNA that remarkably repress cell proliferation. These microRNAs and their targets appear to be promising novel therapeutic targets of pancreatic cancers.
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