The interaction between the pathway of TWEAK-Fn14 and IL-13 in the intestinalepithelial cell regeneration
| Project/Area Number |
21790695
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
KAWASHIMA Rei 独立行政法人国立国際医療研究センター, 研究所・肝炎・免疫研究センター消化器疾患研究部, 客員研究員 (70392389)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 消化管上皮細胞傷害 / サイトカイン / アポトーシス / IL-13 / IL-4 / 消化管上皮細胞 / TWEAK |
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| Research Abstract |
We demonstrate that TNF-α -induced intestinal epithelial cell damage partially dependend on TWEAK/Fn14 as well as IL-13. TNF-α, IL-13 and TWEAK/Fn14 synergistically contribute to theperpetuation and aggravation of intestinal inflammation, such as ulcerative colitis.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] TWEAK/Fn14 Pathway : a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.2009
Author(s)
Dohi T, Borodovsky A, Wu P, Shearstone JR, Kawashima R, Runkel L, Rajman L, Dong X, Scott ML, Michaelson JS, Jakubowski A, Burkly LC
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Journal Title
Gastroenterology 136
Pages: 912-923
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[Presentation] Effect of Combination Treatment With TNF-Inhibitor and Anti-TWEAK Antibody in Mouse Colitis Model.2010
Author(s)
Dohi, T., Kawashima, R., Kawamura, Y., I., Michaelson, J., Burkly, L.C
Organizer
Digestive Disease Week 2010 Annual Meeting,poster
Place of Presentation
New Orleans, USA
Related Report
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[Presentation] Multiple Functions of Glycoprotein 2 (Gp2) in the Gastrointestinal Systems ; A Link to Sorting, Packaging and Recycling of the Digestive Enzymes in the Exocrine Pancreas.2010
Author(s)
Tokuhira, Y., Suzuki, R., Kawashima, R., Fukuoka, S.I
Organizer
Digestive Disease Week Annual Meeting,poster
Place of Presentation
New Orleans, USA
Related Report
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[Presentation] Intraperitoneal Secretion of Cytokines and Chemokines in Response to the Surgical Stress.2009
Author(s)
Kawashima, R., Kawamura, Y., I., Phongsisay, V., Okada, T., Toyama-Sorimachi, N., Kawamura Y., J., Konishi, F., Dohi, T
Organizer
Digestive Disease Week Annual Meeting, poster
Place of Presentation
Chicago, USA
Related Report
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