Role of the interaction of extracellular matrix with integrin in the cardiovascular disease

• Project/Area Number: 21790696
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: MATSUI Yutaka Hokkaido University, 遺伝子病制御研究所, 特任准教授 (30431381)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 分子心臓病態学 / 分子血管病態学 / 細胞外マトリックス / 心血管疾患 / 組織再構築 / インテグリン

Research Abstract

The interactions between extracellular matrix proteins and integrins play pivotal roles in the development of many cardiovascular diseases, including cardiac remodeling after myocardial infarction (MI) and atherosclerosis. We had two major novel findings as below. 1) Syndecan-4 and alpha9 integrin plays a critical role in the cardiac healing process after MI. 2) Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization.

Research Products

• [Journal Article] CSF-1-Dependent Red Pulp Macrophages Regulate CD4 T Cell Responses. (2011)
  • Author(s): Kurotaki, D., Matsui, Y., et al
  • Journal Title: J Immunol. 186 Pages: 2229-2229
  • Peer Reviewed
• [Journal Article] Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. (2011)
  • Author(s): Ikesue M, et al
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] CSF-1-Dependent Red Pulp Macrophages Regulate CD4 T Cell Responses. (2011)
  • Author(s): Kurotaki D, et al
  • Journal Title: J Immunol. Volume: 186:2229 Pages: 2229-2237
  • Peer Reviewed
• [Journal Article] Blockade of interaction of alpha9 integrin with its ligands hinders the formation of granulation in cutaneous wound healing. (2010)
  • Author(s): Nakayama, Y., Matsui, Y., et al
  • Journal Title: Lab Invest. 90 Pages: 881-881
  • Peer Reviewed
• [Journal Article] Osteopontin ; as a target molecule for the treatment of inflammatory diseases. (2010)
  • Author(s): Morimoto, J., Matsui, Y., et al
  • Journal Title: Curr Drug Targets. 11 Pages: 494-494
  • Peer Reviewed
• [Journal Article] Blockade of interaction of alpha9 integrin with its ligands hinders the formation of granulation in cutaneous wound healing. (2010)
  • Author(s): Nakayama Y, et al
  • Journal Title: Lab Invest Volume: 90 Pages: 881-894
  • Peer Reviewed
• [Journal Article] Regulatory role of DC-derived osteopontin in systemic allergen sensitization. (2009)
  • Author(s): Kurokawa, M., Matsui, Y., et al
  • Journal Title: Eur J Immunol. 39 Pages: 3323-3323
  • Peer Reviewed
• [Journal Article] Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice. (2009)
  • Author(s): Matsui, Y., Matsui, Y., et al
  • Journal Title: Arthritis Rheum. 60 Pages: 2362-2362
  • Peer Reviewed
• [Journal Article] Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. (2009)
  • Author(s): Kanayama, M., Matsui, Y., et al
  • Journal Title: J Immunol. 182 Pages: 8015-8015
  • Peer Reviewed
• [Journal Article] Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis (2009)
  • Author(s): Kanayama M, et al.
  • Journal Title: J Immunol 182 Pages: 8015-8025
  • Peer Reviewed
• [Journal Article] Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice (2009)
  • Author(s): Matsui Y, et al.
  • Journal Title: Arthritis Rheum 60 Pages: 2362-2371
  • Peer Reviewed
• [Journal Article] Regulatory role of DC-derived osteopontin in systemic allergen sensitization (2009)
  • Author(s): Kurokawa M, et al.
  • Journal Title: Eur J Immunol. 39 Pages: 3323-3330
  • Peer Reviewed
• [Journal Article] (corresponding author、equally contributed) Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization.
  • Author(s): Ikesue, M., Matsui, Y., et al
  • Journal Title: Arterioscler Thromb Vasc Biol. In press
  • Peer Reviewed
• [Presentation] Role of Syndecan-4 in Neointimal Hyperplasia and Atherosclerosis. (2010)
  • Author(s): Masahiro Ikesue, Yutaka Matsui, et al.
  • Organizer: American Heart Association scientific sessions 2010(米・シカゴ)
• [Presentation] 心筋梗塞におけるSyndecan4の機能解析 (2010)
  • Author(s): 松井裕
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] Role of Syndecan-4 in Neointimal Hyperplasia and Atherosclerosis. (2010)
  • Author(s): Masahiro Ikesue, Yutaka Matsui, et al.
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology 2010 scientific sessions (米・サンフランシスコ)
• [Presentation] Interleukin-17 Deficiency Accelerates Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice. (2010)
  • Author(s): Keiko Danzaki, Yutaka Matsui, et al.
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology 2010 scientific sessions (米・サンフランシスコ)
• [Presentation] 心筋梗塞におけるSyndecan4の機能解析 (2010)
  • Author(s): 松井裕
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京 京王プラザホテル
• [Presentation] Syndecan-4 protects from cardiac rupture and dysfunction after myocardial infarction (2009)
  • Author(s): 松井裕, et al.
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] 心筋梗塞における Syndecan-4 の機能解析 (2009)
  • Author(s): 松井裕, 他
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 札幌、北海道大学遺伝子病制御研究所
  • Year and Date: 2009-09-12
• [Presentation] The role of osteopontin in the cardiovascular diseases (2009)
  • Author(s): 松井裕, et al.
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋、名古屋国際会議場
  • Year and Date: 2009-06-02
• [Presentation] Syndecan-4 protects from cardiac rupture and dysfunction after myocardial infarction. (2009)
  • Author(s): Yutaka Matsui, Masahiro Ikesue, Daichi Ohta, Keiko Danzaki, Tetsuhito Kojima, Toshimitsu Uede
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] The role of osteopontin in the cardiovascular diseases. (2009)
  • Author(s): Yutaka Matsui, Toshimitsu Uede
  • Organizer: 第61回日本細胞生物学会Workshop
  • Place of Presentation: 名古屋