| Project/Area Number |
21790697
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKEDA Morihiko Tohoku University, 病院, 助教 (30375084)
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| Research Collaborator |
HAO Kiyotaka 東北大学, 大学院・医学系研究科, 大学院生
KIKUCHI Yoku 東北大学, 大学院・医学系研究科, 大学院生
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 体外衝撃波治療法 / 血管新生 / 慢性心不全 / 体外衝撃波 / 心筋再生 |
|---|
| Research Abstract |
We demonstrated that the shockwave treatment applied to cultured human umbilical vein endothelial cells up-regulated mRNA expression of vascular endothelial growth factor, although further studies are required to determine the optimal condition of the shockwave treatment. Extracorporeal shockwave therapy applied to a rat experimental model of chronic heart failure induced a tendency to improve a left ventricular contractile function and a survival rate as well as a significant increase of capillary density in myocardium.
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