Cyclophilin A Mediates Pulmonary Vascular Remodeling by Rho-kinase Activation in Patients with Pulmonary Hypertension
| Project/Area Number |
21790698
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
SATOH Kimio Tohoku University, 大学院・医学系研究科, 助教 (80436120)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 酸化ストレス / 肺高血圧 / 血管平滑筋細胞 / 低酸素 / 低酸素ストレス / 大動脈瘤 / 心不全 / 心肥大 |
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| Research Abstract |
We tested the hypothesis that CyPA contributes to pulmonary vascular remodeling in PAH patients. Our results provide the direct evidence that the CyPA/Rho-kinase pathway plays an important role in the pathogenesis of PAH in humans.
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.2011
Author(s)
Satoh K, Nigro P, Zeidan A, Soe NN, Jaffre F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC.
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Journal Title
Arterioscler Thromb Vasc Biol. 31
Pages: 1116-1123
Related Report
Peer Reviewed
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