| Project/Area Number |
21790699
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
WAKAYAMA Yuji Tohoku University, 病院, 助教 (10375082)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 突然死 / 心室性不整脈 / 心臓再同期療法 / 植え込み型除細動器 / 左室逆リモデリング / 重症心不全 / 心臟再同期療法 / 画像診断法 |
|---|
| Research Abstract |
We studied the effect of cardiac resynchronization therapy (CRT) on life-threatening ventricular arrhythmias and sudden cardiac deaths in patients with chronic heart failure in Tohoku University Hospital (n=63). CRT reduced the number of premature ventricular contractions using a Holter monitoring. Furthermore, CRT reduced life-threatening ventricular arrhythmias through improving the status of heart failure, especially left ventricular (LV) reverse remodeling (i.e. reduction of LV volume after CRT). CRT-defibrillators (CRT-D) for primary prevention of sudden cardiac deaths also showed the beneficial effect on reduction in ventricular arrhythmias.
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