| Project/Area Number |
21790701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
SHISHIDO Tetsuro Yamagata University, 医学部, 助教 (60400545)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 慢性心不全 / 糖尿病 / SUMOylation |
|---|
| Research Abstract |
Clarify the mechanisms by which aging and diabetes are independent factor for the advancing the heart failure after myocardial infarction contribute to find a new therapeutic target for chronic heart failure. As shown in previous reports using animal model, we found that oxidative stress is increased in patients with heart failure, moreover, its concentration is associated with the severity and prognosis. We found the important role of DGKalpha, which exist in human heart but not in mice, in the process of ischemia reperfusion injury. We also found that oxidative stress modulated the kinase cascade, and modulated the SUMOylation and ubiquitination, finally induced myocardial injury.
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