A role of muscle-restricted coiled-coil protein (MURC) in cardiac hypertrophy and heart failure

• Project/Area Number: 21790703
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: OGATA TAKEHIRO Kyoto Prefectural University of Medicine, 医学部附属病院, 専攻医 (10402877)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 筋特異的遺伝子 / 心肥大 / 心不全

Research Abstract

MURC expression was increased in cardiac hypertrophy and failing hearts. When MURC was overexpressed in CMs, MURC induced ERK activation and cardiomyocyte (CM) hypertrophy. shRNA-mediated MURC knockdown impaired α1 adrenergic agonist-induced CM hypertrophy and ERK activation. MURC-induced increases in cell size were attenuated by a MEK inhibitor. Furthermore, MURC bound to cavin family proteins (cavin-1, -2), caveolin-3, α1 adrenergic receptor, and p-ERK in CMs.

Research Products

• [Journal Article] PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes. (2010)
  • Author(s): Isodono K, Takahashi T, Imoto H, Nakanishi N, Ogata T, Asada S, Adachi A, Ueyama T, Oh H, Matsubara H.
  • Journal Title: PLoS One. 5(3)
  • Peer Reviewed
• [Journal Article] PARM-1 is an Endoplasmic Reticulum Molecule Involved in Endoplasmic Reticulum Stress-induced Apoptosis in Rat Cazdiac Myocytes. (2010)
  • Author(s): 五十殿弘二、小形岳寛, 他
  • Journal Title: PLoS ONE Volume: 5
  • Peer Reviewed
• [Journal Article] MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. (2008)
  • Author(s): Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Harada K, Takahashi T, Shioi T, Matsubara H, Oh H.
  • Journal Title: Mol Cell Biol. 28(10) Pages: 3424-3436
  • Peer Reviewed
• [Journal Article] MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis. (2008)
  • Author(s): Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H.
  • Journal Title: AmJ Physiol Cell Physiol. 295(2)
  • Peer Reviewed
• [Presentation] MURC, Muscle-restricted coiled-coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes. (2010)
  • Author(s): Taniguchi T, Ogata T, Naito D, Nakanishi N, Miyagawa K, Amano K, Isodono K, Imoto H, Tagawa M, Takehara N, Asada S, Adachi A, Morimoto M, Takahashi T, Oh H, Ueyama T, Matsubara H.
  • Organizer: AHA Scientific Sessions
  • Place of Presentation: Chicago IL. USA
  • Year and Date: 2010-11-17
• [Presentation] MURC, Muscle-Restricted Coiled-coil Protein, Regulates Caveolae Morphology and Induces Hypertrophy in Cardiomyocytes. (2010)
  • Author(s): 谷口琢也、小形岳寛, 他
  • Organizer: American Heart Association
  • Place of Presentation: シカゴ、アメリカ
  • Year and Date: 2010-11-17
• [Presentation] Cavin familyとしてのMURCの役割およびMURCの心筋疾患に及ぼす影響とメカニズムの検討 (2010)
  • Author(s): 中西直彦, 小形岳寛, 上山知己, 宮川浩太郎, 内藤大督, 谷口琢也, 松原弘明
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡,日本
  • Year and Date: 2010-10-15
• [Presentation] Cavin familyとしてのMURCの役割およびMURCの心筋疾患に及ぼす影響とメカニズムの検討 (2010)
  • Author(s): 中西直彦、小形岳寛, 他
  • Organizer: 日本高血圧学会
  • Place of Presentation: 奈良、日本
  • Year and Date: 2010-10-15
• [Presentation] MURC Induces Cardiomyocyte Hypertrophy Through The Extracellular Signal-regulated Kinase Pathway. (2010)
  • Author(s): 内藤大督、小形岳寛, 他
  • Organizer: International Symposium on Cazdiovasculaz Endocrinology and Metabolism
  • Place of Presentation: 奈良、日本
  • Year and Date: 2010-04-01
• [Presentation] MURC induces cardiomyocyte hypertrophy through the extracellular signal-regulated kinase pathway. (2010)
  • Author(s): Naito D, Ogata T, Amano K, Taniguchi T, Isodono K, Imoto H, Adachi A, Takahashi T, Ueyama T, Matsubara H.
  • Organizer: International Symposium on Cardiovascular Endocrinology and Metabolism
  • Place of Presentation: Nara, Japan