| Project/Area Number |
21790703
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OGATA TAKEHIRO Kyoto Prefectural University of Medicine, 医学部附属病院, 専攻医 (10402877)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 筋特異的遺伝子 / 心肥大 / 心不全 |
|---|
| Research Abstract |
MURC expression was increased in cardiac hypertrophy and failing hearts. When MURC was overexpressed in CMs, MURC induced ERK activation and cardiomyocyte (CM) hypertrophy. shRNA-mediated MURC knockdown impaired α1 adrenergic agonist-induced CM hypertrophy and ERK activation. MURC-induced increases in cell size were attenuated by a MEK inhibitor. Furthermore, MURC bound to cavin family proteins (cavin-1, -2), caveolin-3, α1 adrenergic receptor, and p-ERK in CMs.
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