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Development of new strategy by manipulating autophagy against cardiac failure

Research Project

Project/Area Number 21790714
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionGifu University

Principal Investigator

KANAMORI Hiromitsu  Gifu University, 医学部附属病院, 助教 (20456502)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords分子心臓病態学 / オートファジー / 心筋梗塞 / 慢性心不全 / 左室リモデリング / エネルギー代謝 / 飢餓 / 急性心筋梗塞 / 心機能 / 梗塞サイズ / ATG5siRNA / LAMP-2siRNA
Research Abstract

Starvation-induced autophagy compensated energy by digesting own constituents and maintained cardiac function. Autophagy emerged in acute myocardial infarction and suppressed cardiomyocyte death and limited infarct expansion. Autophagy protected progression of postinfarction cardiac remodeling and improved cardiac dysfunction. These present findings suggest that auophagy is innate and potent protective mechanism and augmenting autophagy could be a useful new therapeutic strategy for myocardial infarction.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Autophagy limits acute myocardial infarction induced by permanent coronary artery occulusion.2011

    • Author(s)
      Kanamori H, Takemura G, Goto K, Maruyama R, Ono K, Nagao K, Tsujimoto A, Ogino A, Takeyama T, Kawaguchi T, Watanabe T, Kawasaki M, Fujiwara T, Fujiwara H, Seishima M, Minatoguch S.
    • Journal Title

      Am J Phisiol Heart Circ Phisiol in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of emerging autophagy in postinfarction cardiac remodeling.2011

    • Author(s)
      Kanamori H, Takemura G, Goto K, Maruyama R, Tsujimoto A, Ogino A, Takeyama T, Kawaguchi T, Watanabe T, Fujiwara T, Fujiwara H, Seishima M, Minatoguchi S.
    • Journal Title

      Cardiovascular Research in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy maintains cardiac function in the starved adult.2009

    • Author(s)
      Takemura G, Kanamori H, Goto K, Maruyama R, Tsujimoto A, Fujiwara H, Seishima M, Minatogichi S.
    • Journal Title

      Autophagy 5(7)

      Pages: 1034-1036

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional significance and morphological characterization of starvation-induced autophagy in the adult heart.2009

    • Author(s)
      Kanamori H, Takemura G, Maruyama R, Goto K, Tsujimoto A, Ogino A, Li L, Kawamura I, Takeyama T, Kawaguchi T, Nagashima K, Fujiwara T, Fujiwara H, Seishima M, MInatoguchi S.
    • Journal Title

      Am J Pathol 174

      Pages: 1705-1714

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional significance and morphological characterization of starvation-induced autophagy in the adult heart.2009

    • Author(s)
      Kanamori H
    • Journal Title

      American journal of pathology 174(5)

      Pages: 1705-1714

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy maintains cardiac function in the starved adult.2009

    • Author(s)
      Kanamori H, Takemura G
    • Journal Title

      autophagy 5(1)

      Pages: 90-92

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      金森寛充
    • Journal Title

      分子血管病 12Vol.10 no.6 2009 10

      Pages: 76-78

    • Related Report
      2009 Annual Research Report
  • [Presentation] Autophagy Limits Expansion of Acute Myocardial Infarction Induced by Permanent Coronary Artery Occlusion2010

    • Author(s)
      Hiromitsu Kanamori, Genzou Takemura, Rumi Maruyama, Kazuko Goto, Akiko Tsujimoto, Koh Ono, Kazuya Nagao, Atsushi Ogino, Itta Kawamura, Toshiaki Takeyama, Tomonori Kawaguchi, Takatomo Watanabe, Takako Fujiwara, Hisayoshi Fujiwara, Mitsuru Seishima, Shinya Minatoguchi
    • Organizer
      第14回日本心不全学会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性心筋梗塞におけるオートファジーのプロセスと心筋保護的役割2010

    • Author(s)
      金森寛充、竹村元三、清島満、湊口信也
    • Organizer
      第19回日本Cell Death学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Cardiomyocyte Autophagy is an Innate Protective Mechanism against Progression of Postinfarction Cardiac Remodeling2010

    • Author(s)
      Hiromitsu Kanamori, Genzou Takemura, Kazuko Goto, Rumi Maruyama, Akiko Tsujimoto, Itta Kawamura, Toshiaki Takeyama, Tomonori Kawaguchi, Takatomo Watanabe, Atsushi Ogino, Takako Fujiwara, Hisayoshi Fujiwara, Mitsuru Seishima, Shinya Minatoguchi
    • Organizer
      第74回日本循環器学会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Autophagy Limits Expansion of Acute Myocardial Infarction Induced by Permanent Coronary Artery Occlusion2010

    • Author(s)
      金森寛充
    • Organizer
      第14回日本心不全学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性心筋梗塞におけるオートファジーのプロセスと心筋保護的役割2010

    • Author(s)
      金森寛充
    • Organizer
      第19回日本Cell Death学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cardiomyocyte Autophagy is an Innate Protective Mechanism against Progression of Postinfarction Cardiac Remodeling2010

    • Author(s)
      金森寛充
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Autophagy Limits Acute Myocardial Infarct Expansion.2009

    • Author(s)
      Hiromitsu Kanamori, Genzou Takemura, Tomonori Kawaguchi, Toshiaki Takeyama, Itta Kawamura, Kazuko Goto, Longhu Li, Hisayoshi Fujiwara, Mitsuru Seishima, Shinya Minatoguchi
    • Organizer
      17th Asia Pacific Congress of Cardiology. 17^<th> APCC Kyoto Japan 2009
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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