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The relationship between protein levels and physiological parameters for cardiomyopathy

Research Project

Project/Area Number 21790716
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionNagoya University

Principal Investigator

HIRASHIKI Akihiro  Nagoya University, 医学部附属病院, 病院助教 (10418741)

Research Collaborator SAKAKIBARA Masaki  名古屋大学, 医学部附属病院・循環器内科, 医員
OHSHIMA Kei  名古屋大学, 医学部附属病院・循環器内科, 医員
OKUMURA Takahiro  名古屋大学, 大学院・医学系研究科・循環器内科学, 大学院
BANDO Yasuko  名古屋大学, 大学院・医学系研究科・循環器内科学, 助教
SEI Kenbu  名古屋大学, 大学院・医学系研究科・循環器内科学, 特任講師
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords慢性心不全 / 心筋特性 / 予後予測因子 / 心機能 / 拡張型心筋症 / 肥大型心筋症 / 心筋線維化 / 心筋mRNA / 心筋蛋白 / 予後
Research Abstract

To clarify pathophysiological mechanisms, we performed the pathophysiological analysis about the amounts of Ca-handling protein mRNAs levels and the hemodynamic parameters in patients with cardiomyopathy. In 2010, we reported that the relationship between dobutamine-induced mechanical alternans and mRNA levels of Ca-handling protein in patients with dilated cardiomyopathy. In 2009, Mitochondria showed functional impairment and morphological disorganization in the left ventricle of HCM patients. These mitochondrial changes were associated with impaired myocardial contractile and relaxation reserves.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (11 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Association of diabetes mellitus with myocardial collagen accumulation and relaxation impairment in patients with dilated cardiomyopathy.2011

    • Author(s)
      Sakakibara M, Hirashiki A, Cheng XW, Bando Y, Ohshima K, Okumura T, Funahashi H, Ohshima S, Murohara T.
    • Journal Title

      Diabetes Res Clin Pract.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure.2011

    • Author(s)
      Funahashi H, Izawa H, Hirashiki A, Cheng XW, Inden Y, Nomura M, Murohara T.
    • Journal Title

      J Cardiol.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of diabetes mellitus with myocardial collagen accumulation and relaxation impairment in patients with dilated cardiomyopathy2011

    • Author(s)
      Masaki Sakakibara
    • Journal Title

      Diabetes research and clinical practice

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between cardiopulmonary exercise and dobutamine stress testing in ambulatory patients with idiopathic dilated cardiomyopathy : A comparison with peak VO2 and VE/VCO2 slope2011

    • Author(s)
      Takahiro Okumura
    • Journal Title

      Internal Journal of Cardiology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dobutamine-induced mechanical alternans is a marker of poor prognosis in idiopathic dilated cardiomyopathy.2010

    • Author(s)
      Hirashiki A, Izawa H, Cheng XW, Unno K, Ohshima S, Murohara T.
    • Journal Title

      Clin Exp Pharmacol Physiol. 37(10)

      Pages: 1004-1009

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特発性拡張型心筋症患者におけるExercise Oscillatory Ventilationに関する検討2010

    • Author(s)
      奥村貴裕、平敷安希博、住田佳陽、清水優子、河野裕治、竹下享典、山田純生、室原豊明
    • Journal Title

      心臓リハビリテーション 15

      Pages: 120-125

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy.2010

    • Author(s)
      Unno K, Shibata R, Izawa H, Hirashiki A, Murase Y, Yamada T, Kobayashi M, Noda A, Nagata K, Ouchi N, Murohara T.
    • Journal Title

      Heart. 96(5)(Epub 2009 Jul 30.)

      Pages: 357-361

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dobutamine-induced mechanical alternans is a marker of poor prognosis in idiopathic dilated cardiomyopathy.2010

    • Author(s)
      Akihiro Hirashiki
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 37 Pages: 1004-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or midly symptomatic patients with heart failure : comparison with azosemide.2009

    • Author(s)
      Ken Harada
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 6 Pages: 468-73

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy.2009

    • Author(s)
      Kazumasa Unno
    • Journal Title

      Eur Heart J.

      Volume: 30 Pages: 1853-62

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Diastolic Stiffening of the Failing Myocardium and Its Prevention by Angiotensin Receptor and Calcium Channel Blockers.2009

    • Author(s)
      Xian Wu Cheng
    • Journal Title

      J Cardiovasc Pharmacol.

      Volume: 54 Pages: 47-56

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of pulse wave velocity in a Japanese population with metabolic syndrome.2009

    • Author(s)
      Akihiro Hirashiki
    • Journal Title

      Hypertens Res.

      Volume: 32 Pages: 1045-6

    • NAID

      10026124620

    • Related Report
      2009 Annual Research Report
  • [Presentation] The Complication of Both Sleep-Disordered Breathing and Chronic Kidney Disease are Associated With Poor Prognosis in Patients With Idiopathic Dilated Cardiomyopathy.2010

    • Author(s)
      Hirashiki A, Okumura T, Shinoda N, Ohshima S, Murohara T.
    • Organizer
      American Heart Association, 83th Scientific Sessions 2010
    • Place of Presentation
      Chicago, America, McCormick Place Convention Center
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] The Complication of Both Sleep-Disordered Breathing and Chronic Kidney Disease are Associated With Poor Prognosis in Patients With Idiopathic Dilated Cardiomyopathy.2010

    • Author(s)
      Hirashiki A
    • Organizer
      American Heart Association, 83th Scientific Sessions 2010
    • Place of Presentation
      Chicago.(アメリカ)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pressure Half-Time is an Independent Predictor of Prognosis in Patients With Idiopathic Dilated Cardiomyopathy.2010

    • Author(s)
      Hirashiki A
    • Organizer
      Hirashiki A, Okumura T, Ohshima K, Sakakibara M, Funahashi H, Ohshima S, Murohara T.
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pressure-Half time is an independent predictor of prognosis in patients with nonischemic dilated cardiomyopathy.2010

    • Author(s)
      Akihiro Hirashiki
    • Organizer
      第74回 日本循環器学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Relationship between myocardial contractile reserve measured by dobutamine stress testing and peak oxygen consumption in patients with idiopathic dilated cardiomyopathy.2010

    • Author(s)
      Okumura T, Hirashiki A, Ohshima K, Sakakibara M, Funahashi H, Yuji K, Takeshita K, Cheng XW, Yamada S, Murohara T.
    • Organizer
      World Congress of Cardiology Scientific Sessions 2010
    • Place of Presentation
      Beijing, China, China National Convention Centre
    • Related Report
      2010 Final Research Report
  • [Presentation] Pressure Half-Time is an Independent Predictor of Prognosis in Patients With Idiopathic Dilated Cardiomyopathy.2010

    • Author(s)
      Hirashiki A, Okumura T, Ohshima K, Sakakibara M, Funahashi H, Ohshima S, Murohara T.
    • Organizer
      World Congress of Cardiology Scientific Sessions 2010
    • Place of Presentation
      Beijing, China, China National Convention Centre
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺動脈性肺高血圧症に対するCPXでの重症度・治療効果判定の経験2009

    • Author(s)
      平敷安希博
    • Organizer
      第15回 日本心臓リハビリテーション学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Association Between Myocardial Contractile Reserve By Dobutamine Stress Testing And Cardiopulmonary Exercise Testing Variables In Patients With Idiopathic Dilated Cardiomyopathy.2009

    • Author(s)
      Okumura T, Hirashiki A, Ohshima K, Sakakibara M, Funahashi H, Ohshima Satoru, Kono Y, Takeshita K, Izawa H, Yamada S, Yokota M, Murohara T.
    • Organizer
      American Heart Association, 82th Scientific Sessions 2009
    • Place of Presentation
      Orland, America, Orange County Convention Center
    • Related Report
      2010 Final Research Report
  • [Presentation] Diabetes mellitus is associated with impairment of myocardial relaxation and accumulation of collagen in patients with dilated cardiomyopathy.2009

    • Author(s)
      Sakakibara M, Hirashiki A, Cheng XW, Bando Y, Ohshima K, Okumura T, Funahashi H, Ohshima S, Noda A, Izawa H, Murohara T.
    • Organizer
      American Heart Association, 82th Scientific Session 2009
    • Place of Presentation
      Orland, America, Orange County Convention Center
    • Related Report
      2010 Final Research Report
  • [Presentation] Pressure-Half time as an independent predictor of prognosis in patients with nonischemic dilated cardiomyopathy.2009

    • Author(s)
      Hirashiki A, Izawa H, Okumura T, Ohshima K, Sakakibara M, Funahashi H, Yokota M, Murohara T.
    • Organizer
      ESC congress 2009
    • Place of Presentation
      Barcerona, Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] Dobutamine-induced mechanical alternans is a good useful predictor of poor prognosis in asymptomatic or mildly patients with idiopathic dilated cardiomyopathy.2009

    • Author(s)
      Hirashiki A, Izawa H, Okumura T, Ohshima K, Sakakibara M, Funahashi H, Murohara T.
    • Organizer
      ESC congress 2009
    • Place of Presentation
      Barcerona, Spain
    • Related Report
      2010 Final Research Report
  • [Book] 基礎からの睡眠医学(監修古池保雄 編野田明子中田誠一尾崎紀夫)2010

    • Author(s)
      平敷安希博, 野田明子
    • Publisher
      名古屋大学出版会
    • Related Report
      2010 Final Research Report
  • [Book] 利尿薬循環器臨床サピア8心不全の急性期対応(責任編集北風政史)2010

    • Author(s)
      平敷安希博, 室原豊明
    • Publisher
      中山書店
    • Related Report
      2010 Final Research Report
  • [Book] 心筋細胞外マトリックスと線維診療に活かす心機能評価(編北風政史)2010

    • Author(s)
      平敷安希博, 室原豊明
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report
  • [Book] 心筋細胞外マトリックスと線維(診療に活かす心機能評価)(編北風政史)2010

    • Author(s)
      平敷安希博, 室原豊明
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] 利尿薬(循環器臨床サピア8心不全の急性期対応)(責任編集北風政史)2010

    • Author(s)
      平敷安希博, 室原豊明
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 基礎からの睡眠医学(監修 古池保雄編 野田明子 中田誠一 尾崎紀夫)2010

    • Author(s)
      平敷安希博, 野田明子
    • Publisher
      名古屋大学出版会
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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