| Project/Area Number |
21790716
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
HIRASHIKI Akihiro Nagoya University, 医学部附属病院, 病院助教 (10418741)
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| Research Collaborator |
SAKAKIBARA Masaki 名古屋大学, 医学部附属病院・循環器内科, 医員
OHSHIMA Kei 名古屋大学, 医学部附属病院・循環器内科, 医員
OKUMURA Takahiro 名古屋大学, 大学院・医学系研究科・循環器内科学, 大学院
BANDO Yasuko 名古屋大学, 大学院・医学系研究科・循環器内科学, 助教
SEI Kenbu 名古屋大学, 大学院・医学系研究科・循環器内科学, 特任講師
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 慢性心不全 / 心筋特性 / 予後予測因子 / 心機能 / 拡張型心筋症 / 肥大型心筋症 / 心筋線維化 / 心筋mRNA / 心筋蛋白 / 予後 |
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| Research Abstract |
To clarify pathophysiological mechanisms, we performed the pathophysiological analysis about the amounts of Ca-handling protein mRNAs levels and the hemodynamic parameters in patients with cardiomyopathy. In 2010, we reported that the relationship between dobutamine-induced mechanical alternans and mRNA levels of Ca-handling protein in patients with dilated cardiomyopathy. In 2009, Mitochondria showed functional impairment and morphological disorganization in the left ventricle of HCM patients. These mitochondrial changes were associated with impaired myocardial contractile and relaxation reserves.
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